Zurlo M G, Pastore G, Masera G, Terracini B, Burgio R, Ceci A, Digilio G, Guazzelli C, Haupt R, Lo Curto M
Cancer. 1986 Mar 1;57(5):1052-5. doi: 10.1002/1097-0142(19860301)57:5<1052::aid-cncr2820570530>3.0.co;2-0.
The Italian Registry of Off-Therapy patients after childhood tumors now includes 760 subjects with acute lymphoblastic leukemia. These patients were all removed from treatment by December 31, 1981, and were followed in 35 different institutions. All the children have received multiple-drug treatment, combined, in 79.7% of the cases, with cranial irradiation. Thirty-nine (5%) experienced a relapse before treatment suspension. Total duration of antileukemic therapy ranges between 18 and 131 months (median, 38). At the last updating (December 31, 1981), 699 subjects were alive, 6 were lost to follow-up, and 55 had died. Life-table analysis shows that 90.8% were alive and 77% were alive in continuous complete remission at 36 months, whereas at 66 months, the cumulative proportions were 88% and 75.5%, respectively. One hundred thirty-six of 760 relapses after therapy suspension were reported: 83 in male patients and 53 in female patients (P less than 0.01). The longest interval between relapse and treatment suspension was 64 months. Six of 55 died in continuous complete remission 3 to 44 months after treatment suspension. Five births of apparently normal babies to female patients have been reported. A general outline of the project and the future program are given.
意大利儿童肿瘤治疗后停止治疗患者登记处目前纳入了760例急性淋巴细胞白血病患者。这些患者均在1981年12月31日前结束治疗，并在35个不同机构接受随访。所有儿童均接受了多药联合治疗，79.7%的病例还联合进行了颅脑照射。39例（5%）在治疗中止前复发。抗白血病治疗的总时长在18至131个月之间（中位数为38个月）。在最后一次更新时（1981年12月31日），699例患者存活，6例失访，55例死亡。生命表分析显示，36个月时90.8%的患者存活，持续完全缓解的患者占77%；而在66个月时，累积比例分别为88%和75.5%。报告了760例治疗中止后复发的病例：男性患者83例，女性患者53例（P<0.01）。复发与治疗中止之间的最长间隔为64个月。55例死亡患者中有6例在治疗中止后3至44个月处于持续完全缓解状态。报告了5例女性患者产下表面正常婴儿的情况。给出了该项目的总体概述和未来计划。
