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儿童癌症幸存者的婚姻和育儿状况:来自意大利 AIEOP 治疗后注册处的报告。

Marriage and parenthood among childhood cancer survivors: a report from the Italian AIEOP Off-Therapy Registry.

机构信息

Childhood Cancer Registry of Piedmont, Cancer Epidemiology Unit – CPO Piemonte, CeRMS, S.Giovanni Hospital and University of Turin, Turin, Italy.

出版信息

Haematologica. 2011 May;96(5):744-51. doi: 10.3324/haematol.2010.036129. Epub 2011 Jan 12.

Abstract

BACKGROUND

The aim of this study was to describe the patterns of marriage and parenthood in a cohort of childhood cancer survivors included in the Off-Therapy Registry maintained by the Italian Association of Pediatric Hematology and Oncology.

DESIGN AND METHODS

We analyzed a cohort of 6,044 patients diagnosed with cancer between 1960 and 1998, while aged 0 to 14 years and who were 18 years old or older by December 2003. They were followed up through the regional vital statistics registers until death or the end of follow up (October 30, 2006), whichever occurred first, and their marital status and date of birth of their children were recorded. The cumulative probabilities of being married and having a first child were computed by gender and compared by tumor type within the cohort. Marriage and fertility rates (the latter defined as the number of live births per woman-year) were compared with those of the Italian population of the same age, gender, area of residence and calendar period by means of the observed to expected (O/E) ratios.

RESULTS

During the follow-up period, 4,633 (77%) subjects had not married. The marriage O/E ratios were 0.56 (95% CI: 0.51-0.61) and 0.70 (95% CI: 0.65-0.76) among men and women, respectively. Overall, 263 men had 367 liveborn children, and 473 women had 697 liveborn children. The female fertility O/E ratio was 0.57 (95% CI: 0.53-0.62) overall, and 1.08 (95% CI: 0.99-1.17) when analyses were restricted to married/cohabiting women

CONCLUSIONS

Childhood cancer survivors are less likely to marry and to have children than the general population, confirming the life-long impact of their previous disease on their social behavior and choices. The inclusion of counseling in the strategies of management and long-term surveillance of childhood cancer patients could be beneficial to survivors as they approach adulthood.

摘要

背景

本研究的目的是描述纳入意大利儿科血液学和肿瘤学协会维持的治疗后登记处的儿童癌症幸存者队列中的婚姻和生育模式。

设计与方法

我们分析了一组 6044 名患者,他们于 1960 年至 1998 年间被诊断患有癌症,年龄在 0 至 14 岁之间,截至 2003 年 12 月已满 18 岁。通过区域生命统计记录对他们进行随访,直到死亡或随访结束(2006 年 10 月 30 日),以先发生者为准,并记录他们的婚姻状况和子女的出生日期。按性别计算了结婚和生育第一胎的累积概率,并在队列内按肿瘤类型进行了比较。通过观察与预期(O/E)比值,将结婚率和生育率(后者定义为每妇女-年活产数)与同年龄、性别、居住地和日历期的意大利人口进行了比较。

结果

在随访期间,4633 名(77%)受试者未结婚。男性和女性的婚姻 O/E 比值分别为 0.56(95%CI:0.51-0.61)和 0.70(95%CI:0.65-0.76)。总体而言,263 名男性有 367 名活产子女,473 名女性有 697 名活产子女。女性生育率 O/E 比值总体为 0.57(95%CI:0.53-0.62),当分析仅限于已婚/同居女性时为 1.08(95%CI:0.99-1.17)。

结论

儿童癌症幸存者结婚和生育的可能性低于一般人群,证实了他们以前疾病对其社会行为和选择的终身影响。在儿童癌症患者的管理和长期监测策略中纳入咨询,可能对即将成年的幸存者有益。

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Fertility of female survivors of childhood cancer: a report from the childhood cancer survivor study.
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4
Social outcomes in the Childhood Cancer Survivor Study cohort.
J Clin Oncol. 2009 May 10;27(14):2390-5. doi: 10.1200/JCO.2008.21.1458. Epub 2009 Feb 17.
5
Rates of postcancer parenthood.
J Clin Oncol. 2009 Jan 20;27(3):321-2. doi: 10.1200/JCO.2008.19.7749. Epub 2008 Dec 15.
8
Long term survivors of childhood cancer: cure and care. The Erice statement.
Eur J Cancer. 2007 Aug;43(12):1778-80. doi: 10.1016/j.ejca.2007.04.015. Epub 2007 May 31.
9
Long-term population-based marriage rates among adult survivors of childhood cancer in Britain.
Int J Cancer. 2007 Aug 15;121(4):846-55. doi: 10.1002/ijc.22742.
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Offspring sex ratio and gonadal irradiation in the British Childhood Cancer Survivor Study.
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