Maneschi F, Fugardi M G, Corsello G, LoCurto M
First Department of Obstetrics and Gynaecology, University of Palermo, Italy.
Eur J Pediatr. 1991 Jul;150(9):630-3. doi: 10.1007/BF02072622.
Eleven girls treated during childhood for acute leukaemia were followed up during their pubertal development. At each examination weight, height, pubertal stage, FSH, LH, oestradiol, testosterone, androstenedione and dehydroepiandrosterone sulphate levels were evaluated. Clinical and endocrinological studies were performed according to age and pubertal stage and compared to those of healthy girls matched for age and pubertal stage. Results showed that pubertal maturation and gonadal function were not affected by oncotherapy; however menarche was attained earlier. Early menarche was explained by the overweight of treated girls during early puberty. No evidence of early hypothalamic activation was found, but endocrine patterns showed a faster hypothalamopituitary-ovarian axis maturation in patients than controls. Cranial irradiation showed no correlation with pubertal onset and age at which menarche was attained. Adolescent menstrual and endocrine patterns were normal.
11名儿童期接受急性白血病治疗的女孩在青春期发育期间接受了随访。每次检查时，均评估体重、身高、青春期阶段、促卵泡生成素（FSH）、促黄体生成素（LH）、雌二醇、睾酮、雄烯二酮和硫酸脱氢表雄酮水平。根据年龄和青春期阶段进行临床和内分泌学研究，并与年龄和青春期阶段匹配的健康女孩进行比较。结果显示，青春期成熟和性腺功能未受肿瘤治疗影响；然而，月经初潮提前出现。初潮提前是由于接受治疗的女孩在青春期早期超重所致。未发现下丘脑早期激活的证据，但内分泌模式显示患者的下丘脑-垂体-卵巢轴成熟速度比对照组更快。颅脑照射与青春期开始及月经初潮年龄无关。青少年的月经和内分泌模式正常。
