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本文引用的文献

1
HIV-1 gp120-Induced Endolysosome de-Acidification Leads to Efflux of Endolysosome Iron, and Increases in Mitochondrial Iron and Reactive Oxygen Species.HIV-1 gp120诱导的内溶酶体去酸化导致内溶酶体铁外流，并增加线粒体铁和活性氧。
J Neuroimmune Pharmacol. 2022 Jun;17(1-2):181-194. doi: 10.1007/s11481-021-09995-2. Epub 2021 Apr 8.
2
Iron loading is a prominent feature of activated microglia in Alzheimer's disease patients.铁超载是阿尔茨海默病患者激活的小胶质细胞的一个显著特征。
Acta Neuropathol Commun. 2021 Feb 17;9(1):27. doi: 10.1186/s40478-021-01126-5.
3
Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain.营养不良的小胶质细胞与神经退行性疾病有关，而与人类大脑的健康衰老无关。
Neurobiol Aging. 2021 Mar;99:19-27. doi: 10.1016/j.neurobiolaging.2020.12.003. Epub 2021 Jan 7.
4
Inflaming the Brain with Iron.铁引发脑部炎症
Antioxidants (Basel). 2021 Jan 6;10(1):61. doi: 10.3390/antiox10010061.
5
Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death.氧化还原脂质重编程指挥巨噬细胞和小胶质细胞对铁死亡的敏感性。
Nat Chem Biol. 2020 Mar;16(3):278-290. doi: 10.1038/s41589-019-0462-8. Epub 2020 Feb 17.
6
Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation.维持铁稳态是溶酶体酸性对于细胞增殖的关键作用。
Mol Cell. 2020 Feb 6;77(3):645-655.e7. doi: 10.1016/j.molcel.2020.01.003. Epub 2020 Jan 23.
7
Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo.溶酶体酸化功能障碍引发体内铁缺乏和炎症。
Elife. 2019 Dec 3;8:e51031. doi: 10.7554/eLife.51031.
8
Lysosome biogenesis in health and disease.溶酶体的生物发生与健康和疾病。
J Neurochem. 2019 Mar;148(5):573-589. doi: 10.1111/jnc.14564. Epub 2018 Oct 18.
9
Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis.衰老细胞中的铁积累与铁蛋白自噬受损和铁死亡抑制有关。
Redox Biol. 2018 Apr;14:100-115. doi: 10.1016/j.redox.2017.08.015. Epub 2017 Sep 1.
10
Disorders of lysosomal acidification-The emerging role of v-ATPase in aging and neurodegenerative disease.溶酶体酸化紊乱——V-ATP酶在衰老和神经退行性疾病中的新作用
Ageing Res Rev. 2016 Dec;32:75-88. doi: 10.1016/j.arr.2016.05.004. Epub 2016 May 16.

Iron, the endolysosomal system and neuroinflammation: a matter of balance.

作者信息

Borquez Daniel A, Urrutia Pamela J, Núñez Marco T

机构信息

Center for Biomedical Research, Faculty of Medicine, Universidad Diego Portales, Santiago, Chile.

Department of Biology, Faculty of Sciences, Universidad de Chile, Santiago, Chile.

出版信息

Neural Regen Res. 2022 May;17(5):1003-1004. doi: 10.4103/1673-5374.324847.

DOI:10.4103/1673-5374.324847
PMID:34558520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8552837/
Abstract
摘要