增强的 C NMR 检测活细胞中的扩展反应网络。
Enhanced C NMR detects extended reaction networks in living cells.
机构信息
Department of Health Technology Technical University of Denmark Elektrovej, 349 2800-Kgs. Lyngby, Denmark.
Department of Chemistry Technical University of Denmark Kemitorvet, Bygning 207, 2800 Kgs. Lyngby, Denmark.
出版信息
Chem Commun (Camb). 2021 Oct 12;57(81):10572-10575. doi: 10.1039/d1cc03838a.
Insights into intracellular chemistry have remained sparse, but would be impactful for the advancement of biomedicine and bioproduction. A suitable C NMR approach provides improvements in sensitivity that make extended reaction networks and assay time windows, previously inaccessible cell densities and relative flux measurements accessible in living cells.
细胞内化学的研究一直很匮乏，但这对于推进生物医学和生物生产有重大影响。一种合适的 13C NMR 方法可以提高灵敏度，使以前无法进入的反应网络和检测时间窗口、以前无法达到的细胞密度和相对通量测量在活细胞中变得可行。
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