一名急性早幼粒细胞白血病患者出现变异易位t(3;15)(q21;q22) 。
Variant translocation t(3;15)(q21;q22) in a patient with acute promyelocytic leukemia.
作者信息
Heim S, Kristoffersson U, Mandahl N, Malm C, Mitelman F
机构信息
Department of Clinical Genetics, University Hospital, Lund, Sweden.
出版信息
Leukemia. 1988 Jan;2(1):65-7.
Bone marrow cells from most patients with acute promyelocytic leukemia contain a highly specific cytogenetic rearrangement, a reciprocal translocation between the long arms of chromosomes 15 and 17. Several cases of variant translocations involving 17q but not 15q have been reported, leading to the suggestion that the break in 17q rather than the one in 15q is the crucial change in the regular t(15;17). We describe a hematologically typical case of acute promyelocytic leukemia with a t(3;15)(q21;q22). This is the first report in this leukemia subset of a variant translocation affecting 15q without involvement of 17q.
大多数急性早幼粒细胞白血病患者的骨髓细胞含有一种高度特异性的细胞遗传学重排，即15号和17号染色体长臂之间的相互易位。有几例涉及17q但不涉及15q的变异易位病例已有报道，这表明17q上的断裂而非15q上的断裂是常规t(15;17)中的关键变化。我们描述了一例血液学典型的急性早幼粒细胞白血病病例，其核型为t(3;15)(q21;q22)。这是该白血病亚型中首例报道的影响15q而不涉及17q的变异易位。
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