Wang Dandan, Wang Jing, Li Zixiao, Gu Hongqiu, Yang Kaixuan, Zhao Xingquan, Wang Yongjun
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
China National Clinical Research Center for Neurological Diseases.
Neurol Res. 2022 Apr;44(4):285-290. doi: 10.1080/01616412.2021.1980842. Epub 2021 Sep 24.
Intracerebral hemorrhage (ICH) has a high mortality and morbidity in the world. C-Reaction Protein (CRP) has been demonstrated to be an independent risk factor and could predict the severity and outcome of ischemic stroke. In our study, we aimed to find out the relationship between CRP levels and the severity and outcome of patients with ICH.
This study comes from the Chinese Stroke Center Alliance (CSCA). Patients' basic characteristics and laboratory examination results, including the concentration of CRP were taken from August 2015 to July 2019. Chi-square test and Logistic regression were used to analyze the relationship between different CRP levels and clinical outcome.
A total of 9589 patients with acute ICH were enrolled in our study. In the logistic regression analysis, we found out that high CRP level is an independent risk factor for the prevalence of severe ICH and in-hospital death. After adjusting sex, age and other relevant stroke risk factors, the difference still exists (Severe ICH: odd ratio (OR) (95% confidence interval (CI) = 1.14 (1.04-1.26), P = 0.0076 for CRP between 3-10mg/l group and 1.64 (1.46-1.84), P<0.0001 for CRP>10mg/l group. In-hospital death: OR(95%CI)= 2.03(1.39-2.95), P=0.0002 for CRP>10mg/l group).
High CRP level was independently associated with poorer clinical outcome and higher in-hospital death in patients with ICH.
脑出血（ICH）在全球范围内具有较高的死亡率和发病率。C反应蛋白（CRP）已被证明是一个独立的危险因素，并且可以预测缺血性卒中的严重程度和预后。在我们的研究中，我们旨在找出CRP水平与ICH患者的严重程度和预后之间的关系。
本研究来自中国卒中中心联盟（CSCA）。收集了2015年8月至2019年7月患者的基本特征和实验室检查结果，包括CRP浓度。采用卡方检验和逻辑回归分析不同CRP水平与临床结局之间的关系。
本研究共纳入9589例急性ICH患者。在逻辑回归分析中，我们发现高CRP水平是严重ICH患病率和院内死亡的独立危险因素。在调整性别、年龄和其他相关卒中危险因素后，差异仍然存在（严重ICH：3-10mg/l组CRP的比值比（OR）（95%置信区间（CI））=1.14（1.04-1.26），P=0.0076；CRP>10mg/l组为1.64（1.46-1.84），P<0.0001。院内死亡：CRP>10mg/l组的OR（95%CI）=2.03（1.39-2.95），P=0.0002）。
高CRP水平与ICH患者较差的临床结局和较高的院内死亡率独立相关。
