Taillefer R, Beauchamp G, Léveillé J
Clin Nucl Med. 1986 Jan;11(1):15-9. doi: 10.1097/00003072-198601000-00006.
Fifty-two patients with proven primary lung cancer who were referred for mediastinoscopy were prospectively studied with Tc-99m glucoheptonate and Ga-67 citrate thoracic scintigraphy. Primary lung tumors concentrated Ga-67 in 92% of cases, compared to 88% for Tc-99m glucoheptonate. Mediastinoscopy confirmed the presence of mediastinal metastases in 23 patients. The sensitivity of Tc-99m glucoheptonate and Ga-67 scans for mediastinal involvement detection is respectively 52% and 83%, for a specificity of 100% (Tc-99m glucoheptonate) and 88% (Ga-67). Twenty-nine patients underwent thoracotomy after a negative mediastinoscopy. Hilar metastatic involvement was present in eight patients. The sensitivity and the specificity for detection of hilar involvement were respectively 63% and 95% for Tc-99m glucoheptonate and 88% and 78% for Ga-67. Although more specific than Ga-67 scan, Tc-99m glucoheptonate thoracic imaging cannot be recommended in the staging of lung cancer because of its low sensitivity in the detection of intrathoracic metastatic spread of primary lung carcinoma.
对52例经证实的原发性肺癌患者进行了前瞻性研究，这些患者因纵隔镜检查而被转诊，并接受了99m锝葡庚糖酸盐和67镓柠檬酸盐胸部闪烁扫描。原发性肺肿瘤在92%的病例中浓聚67镓，相比之下，99m锝葡庚糖酸盐浓聚的病例为88%。纵隔镜检查证实23例患者存在纵隔转移。99m锝葡庚糖酸盐和67镓扫描检测纵隔受累的敏感性分别为52%和83%，特异性分别为100%（99m锝葡庚糖酸盐）和88%（67镓）。29例患者在纵隔镜检查阴性后接受了开胸手术。8例患者存在肺门转移受累。99m锝葡庚糖酸盐检测肺门受累的敏感性和特异性分别为63%和95%，67镓分别为88%和78%。尽管99m锝葡庚糖酸盐胸部成像比67镓扫描更具特异性，但由于其在检测原发性肺癌胸内转移扩散方面敏感性较低，因此不建议用于肺癌分期。
