McKenna R J, Haynie T P, Libshitz H I, Mountain C F, McMurtrey M J
Chest. 1985 Apr;87(4):428-31. doi: 10.1378/chest.87.4.428.
Seventy-five patients with lung cancer underwent a gallium scan and thoracotomy with total mediastinal nodal dissection. Evaluation of mediastinal lymph nodes by means of the gallium scan showed a sensitivity of 23 percent (3/13), a specificity of 82 percent (31/38), an accuracy of 67 percent (34/51), a positive predictive valve of 30 percent (3/10), and a negative predictive value of 76 percent (31/41) in those patients whose primary tumors demonstrated uptake of radioactive gallium. The low sensitivity was due to an inability to detect microscopic disease in mediastinal lymph nodes. The specificity was decreased by gallium-67 uptake in enlarged inflamed nodes that contained no metastases. These results do not support the use of the gallium scan in the selection of patients with lung cancer for thoracotomy.
75例肺癌患者接受了镓扫描及开胸手术并进行了全纵隔淋巴结清扫。通过镓扫描评估纵隔淋巴结，在那些原发肿瘤显示摄取放射性镓的患者中，敏感性为23%（3/13），特异性为82%（31/38），准确性为67%（34/51），阳性预测值为30%（3/10），阴性预测值为76%（31/41）。敏感性低是由于无法检测到纵隔淋巴结中的微小病变。肿大的炎症性淋巴结中虽无转移但有镓-67摄取，导致特异性降低。这些结果不支持在选择肺癌患者进行开胸手术时使用镓扫描。
