Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Kagawa University, Kagawa, Japan.
Transl Vis Sci Technol. 2021 Sep 1;10(11):19. doi: 10.1167/tvst.10.11.19.
To investigate whether the resistivity of all retinal vessels, termed total capillary resistance (TCR), after anti-vascular endothelial growth factor (VEGF) treatment was correlated with the outcomes of patients with macular edema secondary to central retinal vein occlusion (CRVO).
In total, 67 patients with nonischemic CRVO were enrolled in this retrospective observational case series. In each patient, we examined visual acuity; central retinal thickness (CRT); mean blur rate (MBR), which represents retinal blood flow velocity; and TCR. MBR and TCR were measured by laser speckle flowgraphy.
During the 1-year follow-up period, nine of 67 eyes (13.4%) converted to the ischemic type (converted group), whereas 58 eyes (86.6%) remained unchanged (nonischemic group). Mean CRT significantly decreased in all groups; however, the mean visual acuity significantly improved only in the nonischemic group. Mean MBR significantly increased in the nonischemic group but remained unchanged in the converted group. Mean TCR was significantly reduced in the nonischemic group but remained unchanged in the converted group. Multiple linear regression analysis revealed that MBR and TCR were the independent factors with the strongest and second strongest correlations with visual acuity after treatment, respectively.
These findings suggest that measurements of the independent factors MBR and TCR are useful for evaluating anti-VEGF treatments in patients with CRVO.
Development of clinically relevant technologies.
探讨抗血管内皮生长因子（VEGF）治疗后所有视网膜血管的电阻率，即总毛细血管阻力（TCR），是否与视网膜中央静脉阻塞（CRVO）继发黄斑水肿患者的治疗结局相关。
本回顾性观察性病例系列研究共纳入 67 例非缺血性 CRVO 患者。对每位患者，我们均检测了视力、视网膜中央厚度（CRT）、代表视网膜血流速度的平均模糊率（MBR）和 TCR。MBR 和 TCR 通过激光散斑血流图进行测量。
在 1 年的随访期间，67 只眼中有 9 只（13.4%）转为缺血型（转化组），而 58 只眼（86.6%）保持不变（非缺血组）。所有组的 CRT 均值均显著降低，但仅在非缺血组的视力均值显著改善。非缺血组的 MBR 均值显著升高，但在转化组中无变化。非缺血组的 TCR 均值显著降低，但在转化组中无变化。多元线性回归分析显示，MBR 和 TCR 是治疗后与视力相关性最强和第二强的独立因素。
这些发现提示，MBR 和 TCR 等独立因素的测量值对于评估 CRVO 患者的抗 VEGF 治疗具有一定的临床应用价值。
