College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
Int J Biol Macromol. 2021 Nov 30;191:344-358. doi: 10.1016/j.ijbiomac.2021.09.093. Epub 2021 Sep 21.
Temperature-sensitive hydrogels have shown good performances as wound dressing owing to their ability to fill wounds in the liquid state and to release drugs in a solid state. However, their treatment efficiency is restricted by the phase transition time. In this study, we developed a photothermal synergistic chitosan-based temperature-sensitive hydrogel, h-EGF-CS/β-GP-MPDA@Cip, with the unique properties of rapid phase transition and drug release under near-infrared light (NIR). High antibacterial efficiency was achieved when we covered infected mice wounds with hydrogels. The local high temperature produced under NIR illumination not only accelerated the formation of a porous gel to release the loaded drug on-demand, but also dissolved bacteria, achieving synergistic anti-bacterial treatment. In addition, the healing cycle of wounds could be significantly shortened by adding human epidermal growth factor (h-EGF) in the hydrogel. Overall, the developed temperature-sensitive hydrogel could utilise NIR as a "trigger switch" for on-demand drug release and photothermal-enhanced antibacterial treatment during the rapid phase change process.
温度敏感水凝胶因其在液态时能填充伤口，在固态时能释放药物的特性，已被证明在用作伤口敷料方面具有良好的性能。然而，其治疗效果受到相变时间的限制。在本研究中，我们开发了一种光热协同壳聚糖基温敏水凝胶 h-EGF-CS/β-GP-MPDA@Cip，它具有在近红外光（NIR）下快速相变和药物释放的独特性能。当我们用水凝胶覆盖感染小鼠的伤口时，实现了高抗菌效率。NIR 光照下产生的局部高温不仅加速了多孔凝胶的形成，从而按需释放负载的药物，还溶解了细菌，实现了协同抗菌治疗。此外，在水凝胶中添加人表皮生长因子（h-EGF）可以显著缩短伤口的愈合周期。总的来说，所开发的温敏水凝胶可以利用 NIR 作为“触发开关”，在快速相变过程中按需释放药物和光热增强的抗菌治疗。
