Department of Human Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, China.
Department of Human Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, China.
Clin Immunol. 2021 Nov;232:108858. doi: 10.1016/j.clim.2021.108858. Epub 2021 Sep 21.
The role of progesterone-induced blocking factor (PIBF)-mediated Th1/Th2 balance in delivery outcomes of in vitro fertilization and embryo transfer (IVF-ET) has not been fully elucidated. In this study, 73 infertile women with successful IVF-ET were enrolled (16 fetal arrests and 57 live births). PIBF and IL-4 levels were significantly lower in the fetal arrest group than in the live birth group (p < 0.05). TNF-α level and Th1/Th2 ratios were significantly higher in the fetal arrest group than in the live birth group (p < 0.05). High TNF-α level and Th1/Th2 ratios were risk factors for fetal arrest, whereas increased PIBF and IL-4 levels were protective factors (P < 0.05). Increased TNF-α/IL-4 exhibited relatively strong predictive value for fetal arrest (AUC, 0.855; sensitivity, 93.8%; specificity, 71.9%). In summary, the PIBF-mediated Th1/Th2 balance is closely correlated with delivery outcomes of IVF-ET. TNF-α/IL-4 may be a predictive marker of fetal arrest.
孕激素诱导阻断因子（PIBF）介导的 Th1/Th2 平衡在体外受精和胚胎移植（IVF-ET）的分娩结局中的作用尚未完全阐明。本研究纳入了 73 例 IVF-ET 成功的不孕妇女（16 例胎儿停育，57 例活产）。胎儿停育组的 PIBF 和 IL-4 水平明显低于活产组（p<0.05）。TNF-α水平和 Th1/Th2 比值在胎儿停育组明显高于活产组（p<0.05）。高 TNF-α水平和 Th1/Th2 比值是胎儿停育的危险因素，而 PIBF 和 IL-4 水平升高是保护因素（P<0.05）。升高的 TNF-α/IL-4 对胎儿停育具有较强的预测价值（AUC，0.855；敏感性，93.8%；特异性，71.9%）。综上所述，PIBF 介导的 Th1/Th2 平衡与 IVF-ET 的分娩结局密切相关。TNF-α/IL-4 可能是胎儿停育的预测标志物。
