Fcγ 受体和新生儿 Fc 受体对树突状细胞功能的调节。

Regulation of dendritic cell function by Fc-γ-receptors and the neonatal Fc receptor.

机构信息

Department of Biochemistry and Pharmacology, The University of Melbourne, Bio21 Molecular Science and Biotechnology Institute, 30 Flemington Rd, Parkville, Victoria, 3010, Australia.

ACRF Translational Research Laboratory, The Royal Melbourne Hospital, Parkville, Melbourne, Victoria, 3050, Australia; Department of Medicine, University of Melbourne, Parkville, Melbourne, Victoria, 3010, Australia.

出版信息

Mol Immunol. 2021 Nov;139:193-201. doi: 10.1016/j.molimm.2021.07.024. Epub 2021 Sep 23.

DOI:10.1016/j.molimm.2021.07.024

PMID:34560415

Abstract

Dendritic cells (DCs) express receptors to sense pathogens and/or tissue damage and to communicate with other immune cells. Among those receptors, Fc receptors (FcRs) are triggered by the Fc region of antibodies produced during adaptive immunity. In this review, the role of FcγR and neonatal Fc receptor (FcRn) in DC immunity will be discussed. Their expression in DC subsets and impact on antigen uptake and presentation, DC maturation and polarisation of T cell responses will be described. Lastly, we will discuss the importance of FcR-mediated DC function in the context of immunity during viral infection, inflammatory disease, cancer and immunotherapy.

摘要

树突状细胞 (DCs) 通过表达受体来感知病原体和/或组织损伤，并与其他免疫细胞进行通信。在这些受体中，Fc 受体 (FcR) 被适应性免疫过程中产生的抗体的 Fc 区域触发。在这篇综述中，将讨论 FcγR 和新生儿 Fc 受体 (FcRn) 在 DC 免疫中的作用。描述它们在 DC 亚群中的表达以及对抗原摄取和呈递、DC 成熟和 T 细胞反应的极化的影响。最后，我们将讨论在病毒感染、炎症性疾病、癌症和免疫治疗期间，FcR 介导的 DC 功能的重要性。