From the Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, PR China; Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province, Luzhou, Sichuan, PR China; and Academician (Expert) Workstation of Sichuan Province, PR China.
Clin Nucl Med. 2022 Mar 1;47(3):246-248. doi: 10.1097/RLU.0000000000003901.
A 66-year-old woman presented with anterior chest wall and knee joints pain and multiple skin lesions. 99mTc-MDP bone scintigraphy showed increased bone density in the sternal angle with abnormal bone metabolism. The patient was enrolled in a 68Ga-DOTA-FAPI-04 PET/CT tumor clinical trial, and it showed increased tracer uptake in the sternum and right knee joint. Subsequently, ultrasound of the right knee joint confirmed the existence of synovitis, and no malignant components were found in sternal biopsy. The patient's final diagnosis was synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. The case confirmed that 68Ga-DOTA-FAPI-04 imaging is helpful for evaluating the involved sites of SAPHO syndrome.
一位 66 岁女性因前胸壁和膝关节疼痛及多处皮肤损伤就诊。99mTc-MDP 骨显像显示胸骨角骨密度增加，伴有异常骨代谢。患者入组了 68Ga-DOTA-FAPI-04 PET/CT 肿瘤临床试验，结果显示胸骨和右膝关节摄取示踪剂增加。随后，右膝关节超声证实存在滑膜炎，胸骨活检未发现恶性成分。患者最终诊断为滑膜炎、痤疮、脓疱病、骨质增生和骨炎（SAPHO）综合征。该病例证实 68Ga-DOTA-FAPI-04 成像有助于评估 SAPHO 综合征的受累部位。
