Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100 Kuala Lumpur, Malaysia.
Department of Medical Sciences, School of Medical and Life Sciences, Sunway University, Jalan Universiti, Bandar Sunway, 47500, Selangor Darul Ehsan, Malaysia.
Carbohydr Polym. 2021 Dec 1;273:118523. doi: 10.1016/j.carbpol.2021.118523. Epub 2021 Aug 4.
Magnetic polymer nanocomposites are inherently multifunctional and harbor assorted physiochemical actions for applications thereof as novel drug nanocarriers. Herein, FeO-nanoparticles were supported on rice straw cellulose for 5-fluorouracil carrier abbreviated as MC/5-FU for potential colorectal cancer treatments. Several analyses indicated the multifunctional properties of MC/5-FU bionanocomposites. Transmission and scanning electron microscopy study demonstrated that FeO nanofillers covered the cellulose matrix. The drug release from MC/5-FU was evaluated under various pH and temperature conditions, showing the maximum release at pH 7.4 and 44.2 °C. In in vitro anticancer assay, MC/5-FU exhibited enhanced selectivity and anticancer actions against 2D monolayer and 3D tumour spheroid models colorectal cancer cells. The anticancer effects of MC/5-FU with magnetic targeting and heat induction were also examined. This easily synthesized MC/5-FU indicated the potential in application as a low-cost drug formulation for colorectal cancer treatments.
磁性高分子纳米复合材料具有固有多功能性，并具有多种物理化学作用，可将其作为新型药物纳米载体。本文中，FeO 纳米颗粒负载在稻草纤维素上，用于 5-氟尿嘧啶载体，简称 MC/5-FU，用于潜在的结直肠癌治疗。多项分析表明，MC/5-FU 生物纳米复合材料具有多功能特性。透射电子显微镜和扫描电子显微镜研究表明，FeO 纳米填料覆盖在纤维素基质上。MC/5-FU 在不同 pH 值和温度条件下的药物释放情况进行了评估，在 pH 7.4 和 44.2°C 时达到最大释放量。在体外抗癌试验中，MC/5-FU 对 2D 单层和 3D 肿瘤球体模型的结直肠癌细胞表现出增强的选择性和抗癌作用。还研究了具有磁靶向和热诱导作用的 MC/5-FU 的抗癌效果。这种易于合成的 MC/5-FU 表明其具有作为结直肠癌治疗低成本药物制剂的应用潜力。
