Key Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu 610065, China; National Engineering Research Center of Clean Technology in Leather Industry, Sichuan University, Chengdu 610065, China.
Key Laboratory of Leather Chemistry and Engineering of Ministry of Education, Sichuan University, Chengdu 610065, China; National Engineering Research Center of Clean Technology in Leather Industry, Sichuan University, Chengdu 610065, China.
Carbohydr Polym. 2021 Dec 1;273:118533. doi: 10.1016/j.carbpol.2021.118533. Epub 2021 Aug 4.
A sensor used to monitor tissue deformation requires good flexibility, stretchability, self-adhesion, cyto-compatibility, and antibacterial property. Here, we prepared hydrogel sensor based on O-carboxymethyl chitosan (O-CMCS) and poly(vinyl alcohol) (PVA) for monitoring human and organ motions. Based on the host-guest complexing of poly(β-cyclodextrin) with diamantane, a cross-linker containing multiple aldehyde groups was prepared for cross-linking with O-CMCS through Schiff base linkages. Borax was used as the second cross-linker to cross-link PVA through dynamic borate ester bonds. Carbon nanotubes (CNTs) were added into the hydrogels to improve their electrical conductivity and mechanical properties. The obtained hydrogel exhibited rapid self-healing ability with healing efficiency as high as 97%-103% (in 15 s), good adhesion to human skin and wet organ, good antibacterial property, cyto-compatibility, and stretchability. Furthermore, the hydrogel sensor can monitor the respiratory movement of porcine lungs and the beating of rat hearts.
一种用于监测组织变形的传感器需要具有良好的柔韧性、拉伸性、自粘性、细胞相容性和抗菌性能。在这里，我们基于 O-羧甲基壳聚糖 (O-CMCS) 和聚乙烯醇 (PVA) 制备了水凝胶传感器，用于监测人体和器官运动。基于聚（β-环糊精）与金刚烷的主客体络合作用，制备了一种含有多个醛基的交联剂，通过席夫碱键与 O-CMCS 交联。硼砂被用作第二种交联剂，通过动态硼酸酯键交联 PVA。将碳纳米管 (CNT) 添加到水凝胶中以提高其电导率和机械性能。所得水凝胶表现出快速的自修复能力，修复效率高达 97%-103%（在 15 秒内），对人体皮肤和湿润器官具有良好的附着力、良好的抗菌性能、细胞相容性和拉伸性。此外，水凝胶传感器可以监测猪肺的呼吸运动和大鼠心脏的跳动。
