Condò Ilaria, Giannitelli Sara Maria, Lo Presti Daniela, Cortese Barbara, Ursini Ornella
Department of Engineering, Università Campus Bio-Medico di Roma, Via Álvaro del Portillo 21, 00128 Rome, Italy.
Department of Science and Technology for Sustainable Development and One Health, Università Campus Bio-Medico di Roma, Via Álvaro del Portillo 21, 00128 Rome, Italy.
Gels. 2024 Jul 4;10(7):442. doi: 10.3390/gels10070442.
Polymeric hydrogels are soft materials with a three-dimensional (3D) hydrophilic network capable of retaining and absorbing large amounts of water or biological fluids. Due to their customizable properties, these materials are extensively studied for developing matrices for 3D cell culture scaffolds, drug delivery systems, and tissue engineering. However, conventional hydrogels still exhibit many drawbacks; thus, significant efforts have been directed towards developing dynamic hydrogels that draw inspiration from organisms' natural self-repair abilities after injury. The self-healing properties of these hydrogels are closely associated with their ability to form, break, and heal dynamic bonds in response to various stimuli. The primary objective of this review is to provide a comprehensive overview of dynamic hydrogels by examining the types of chemical bonds associated with them and the biopolymers utilized, and to elucidate the chemical nature of dynamic bonds that enable the modulation of hydrogels' properties. While dynamic bonds ensure the self-healing behavior of hydrogels, they do not inherently confer adhesive properties. Therefore, we also highlight emerging approaches that enable dynamic hydrogels to acquire adhesive properties.
聚合物水凝胶是一种软材料，具有三维（3D）亲水性网络，能够保留和吸收大量的水或生物流体。由于其可定制的特性，这些材料被广泛研究用于开发3D细胞培养支架、药物递送系统和组织工程的基质。然而，传统水凝胶仍然存在许多缺点；因此，人们付出了巨大努力来开发动态水凝胶，这些动态水凝胶的灵感来源于生物体受伤后的自然自我修复能力。这些水凝胶的自愈特性与其在各种刺激下形成、断裂和修复动态键的能力密切相关。本综述的主要目的是通过研究与动态水凝胶相关的化学键类型和所使用的生物聚合物，对动态水凝胶进行全面概述，并阐明能够调节水凝胶性能的动态键的化学性质。虽然动态键确保了水凝胶的自愈行为，但它们本身并不赋予粘附性能。因此，我们还强调了使动态水凝胶获得粘附性能的新兴方法。
