Pediatric Oncology Branch, NCI, Bethesda, Maryland.
Osteosarcoma Institute, Dallas, Texas.
Cancer Res. 2021 Dec 1;81(23):5783-5799. doi: 10.1158/0008-5472.CAN-21-1191. Epub 2021 Sep 24.
Over the past few years, the field of pediatric cancer has experienced a shift in momentum, and this has led to new and exciting findings that have relevance beyond pediatric malignancies. Here we present the current status of key aspects of pediatric cancer research. We have focused on genetic and epigenetic drivers of disease, cellular origins of different pediatric cancers, disease models, the tumor microenvironment, and cellular immunotherapies.
在过去的几年中，儿科癌症领域的发展势头发生了转变，这带来了新的令人兴奋的发现，这些发现与儿科恶性肿瘤以外的领域相关。在这里，我们介绍儿科癌症研究的当前状况。我们重点介绍了疾病的遗传和表观遗传驱动因素、不同儿科癌症的细胞起源、疾病模型、肿瘤微环境和细胞免疫疗法。
