同步训练对恶性肿瘤患儿身体机能和生活质量的影响：系统评价和荟萃分析。
Effect of concurrent training on physical performance and quality of life in children with malignancy: A systematic review and meta-analysis.
机构信息
Postgraduate School, University of Harbin Sport, Harbin, China.
Xiangya Hospital, Central South University, Changsha, China.
出版信息
Front Public Health. 2023 Mar 17;11:1127255. doi: 10.3389/fpubh.2023.1127255. eCollection 2023.
OBJECTIVE
This study aims to evaluate the intervention effect of concurrent training on children with malignant tumors to provide evidence for prescribing exercise for children with malignant tumors.
METHODS
Twelve databases were searched from inception to October 15, 2022. Two researchers independently screened the literature, evaluated the quality, extracted the data, and performed the meta-analysis using R.
RESULT
A total of nine randomized controlled trials involving 371 children were included in this study. The meta-analysis revealed that muscle strength was significantly greater in the exercise group compared to the usual care group [SMD = 0.26, 95% CI (0.04, 0.48), = 0.023], with subgroup analysis showing no significant difference in upper limb [SMD = 0.13, 95% CI (-0.17, 0.43), = 0.318] and a considerable difference in lower limb strength [SMD = 0.41, 95% CI (0.08, 0.74), = 0.015]. Physical activity [SMD = 0.57, 95% CI (0.03, 1.1), = 0.038], timed up and down stairs test [SMD = -1.22, 95% CI (-2.04, -0.4), = 0.004], 6-min walking ability [SMD = 0.75, 95% CI (0.38, 1.11), < 0.01], quality of life [SMD = 0.28, 95% CI (0.02, 0.53), = 0.033], and cancer-related fatigue [SMD = -0.53, 95% CI (-0.86, -0.19), = 0.002] were significantly better than the usual care group. There were no significant differences in peak oxygen uptake [SMD = 0.13, 95% CI (-0.18, 0.44), = 0.397], depression [SMD = 0.06, 95% CI (-0.38, 0.5), = 0.791], and withdrawal rates [RR = 0.59, 95% CI (0.21, 1.63), = 0.308] between the two groups.
CONCLUSION
Concurrent training could improve physical performance for children with malignancy but had no significant effect on mental health. Because the quality level of evidence is mostly very low, future high-quality randomized controlled trials are required to confirm these findings.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=364140, identifier CRD42022308176.
目的
本研究旨在评估联合训练对恶性肿瘤患儿的干预效果，为恶性肿瘤患儿开具运动处方提供依据。
方法
检索建库至 2022 年 10 月 15 日的 12 个数据库。由 2 名研究人员独立筛选文献、评价质量、提取数据，并使用 R 进行荟萃分析。
结果
共纳入 9 项随机对照试验，涉及 371 名患儿。荟萃分析显示，与常规护理组相比，运动组的肌肉力量显著更大[SMD=0.26，95%CI（0.04，0.48）， =0.023]，亚组分析显示上肢[SMD=0.13，95%CI（-0.17，0.43）， =0.318]差异无统计学意义，下肢力量[SMD=0.41，95%CI（0.08，0.74）， =0.015]差异有统计学意义。身体活动[SMD=0.57，95%CI（0.03，1.1）， =0.038]、计时上下楼梯测试[SMD=-1.22，95%CI（-2.04，-0.4）， =0.004]、6 分钟步行能力[SMD=0.75，95%CI（0.38，1.11）， <0.01]、生活质量[SMD=0.28，95%CI（0.02，0.53）， =0.033]和癌症相关疲劳[SMD=-0.53，95%CI（-0.86，-0.19）， =0.002]明显优于常规护理组。两组间峰值摄氧量[SMD=0.13，95%CI（-0.18，0.44）， =0.397]、抑郁[SMD=0.06，95%CI（-0.38，0.5）， =0.791]和退出率[RR=0.59，95%CI（0.21，1.63）， =0.308]差异均无统计学意义。
结论
联合训练可以提高恶性肿瘤患儿的身体机能，但对心理健康无显著影响。由于证据质量水平大多为极低，需要未来开展高质量的随机对照试验来证实这些发现。
系统评价注册
https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=364140，标识符 CRD42022308176。
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