Department of Gastroenterology, Gastrointestinal Oncology, Hepatology, Infectiology, and Geriatrics, University Hospital Tübingen, 72076, Tübingen, Germany.
Department of Surgery, Kliniken Böblingen, 71032, Böblingen, Germany.
Sci Rep. 2021 Sep 24;11(1):19050. doi: 10.1038/s41598-021-98664-8.
Healing of gastrointestinal ulcers after Hemospray application was reported in literature. The pathophysiological mechanism of action of hemostatic powders is not elucidated so far. A prospective animal model was performed to evaluate the effect of Hemospray application on the healing process of artificially induced ulcers of the upper and lower gastrointestinal tract. In 10 pigs, 20 ulcers were created in each the upper and the lower gastrointestinal tract by endoscopic mucosal resection. 50% of the pigs were immediately treated with Hemospray application, the others were not treated. Ulcer size was measured endoscopically on day 0, 2, and 7. On day 7 the ulcers were histopathological evaluated for capillary ingrowth and the thickness of the collagen layer. After 7 days the sizes of the ulcers decreased significantly (stomach: - 22.8% with Hemospray application, - 19% without Hemospray application; rectum: - 50.8% with Hemospray application, - 49.5% without Hemospray application; p = 0.005-0.037), but without significant difference between both groups. This study shows no significant effect of the hemostatic powder Hemospray on ulcer healing in the upper and lower gastrointestinal tract compared with untreated controls, neither harmful nor beneficial. However, some trends merit further trials in patients and may indicate a possible mechanism of accelerated mucosal healing.
文献中报道了 Hemospray 应用后胃肠道溃疡的愈合情况。止血粉的作用机制尚未阐明。目前已经进行了一项前瞻性动物模型研究，以评估 Hemospray 应用对上消化道和下消化道人工诱导溃疡愈合过程的影响。在 10 头猪中，通过内镜黏膜切除术在上消化道和下消化道各创建 20 个溃疡。其中 50%的猪立即接受 Hemospray 治疗，其余的猪不接受治疗。在第 0、2 和 7 天通过内镜测量溃疡大小。在第 7 天，对溃疡进行组织病理学评估，以评估毛细血管侵入和胶原层的厚度。7 天后，溃疡大小明显缩小（胃：Hemospray 治疗组 -22.8%，未治疗组 -19%；直肠：Hemospray 治疗组 -50.8%，未治疗组 -49.5%；p = 0.005-0.037），但两组之间无显著差异。本研究表明，与未治疗的对照组相比，止血粉 Hemospray 对上消化道和下消化道溃疡愈合没有显著影响，既没有益处也没有害处。然而，一些趋势值得在患者中进一步试验，并可能表明加速黏膜愈合的可能机制。
