微生物视蛋白的发现如何促成了光遗传学的发展。
How the discovery of microbial opsins led to the development of optogenetics.
机构信息
Rockefeller University, New York, NY, USA; Howard Hughes Institute for Medical Research, Chevy Chase, MD, USA.
出版信息
Cell. 2021 Oct 14;184(21):5266-5270. doi: 10.1016/j.cell.2021.08.022. Epub 2021 Sep 24.
PMID:34562360
Abstract
This year's Lasker Award recognizes Dieter Oesterhelt, Peter Hegemann, and Karl Deisseroth for their discovery of microbial opsins as light-activated ion conductors and the development of optogenetics using these proteins to regulate neural activity in awake, behaving animals. Optogenetics has revolutionized neuroscience and transformed our understanding of brain function.
摘要
今年的拉斯克奖授予迪特尔·奥斯特黑尔特、彼得·黑格曼和卡尔·代斯泽罗斯，以表彰他们发现微生物视蛋白作为光激活的离子导体，以及利用这些蛋白质开发光遗传学来调节清醒、行为动物的神经活动。光遗传学彻底改变了神经科学，改变了我们对大脑功能的理解。
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