一名44岁女性的子宫上皮样滋养细胞肿瘤：诊断难题
Uterine Epithelioid Trophoblastic Tumor in a 44-Year-Old Woman: A Diagnostic Dilemma.
作者信息
Aniţei Maria-Gabriela, Lazăr Diana-Elena, Pleşca Raluca Alina, Terinte Cristina, Iulian Radu, Viorel Scripcariu
机构信息
1-st Surgical Oncology Unit, Regional Institute of Oncology, General Henri Mathias Berthelot 2-4, 700483 Iasi, Romania.
Grigore T. Popa, Surgical Department, University of Medicine and Pharmacy, 700115 Iasi, Romania.
出版信息
Clin Pract. 2021 Sep 13;11(3):631-639. doi: 10.3390/clinpract11030078.
BACKGROUND
Epithelioid trophoblastic tumor (ETT) is a rare and newly defined disease, which most commonly occurs in women of reproductive age and can be a sequela of any gestational event. ETT can be present in both intrauterine and extrauterine sites.
CASE REPORT
A woman of reproductive age, without specific comorbidities and with a single pregnancy and natural childbirth eight years ago, was diagnosed initially with poorly differentiated pleomorphic leiomyosarcoma on the hemostatic uterine curettage.
CONCLUSION
Our case highlights that ETT presents a diagnostic challenge due to its rarity and histologic resemblance to other pathologies. Misdiagnosis delays effective treatment and affects survival. To date, only 8 cases of ETT of the uterus without previous gestational event and normal human chorionic gonadotropin (β-HCG) levels in a 60-year literature survey have been reported.
背景
上皮样滋养细胞肿瘤（ETT）是一种罕见的新定义疾病，最常发生于育龄女性，可能是任何妊娠事件的后遗症。ETT可发生于子宫内和子宫外部位。
病例报告
一名育龄女性，无特殊合并症，8年前曾单胎妊娠并自然分娩，因子宫止血刮宫术最初被诊断为低分化多形性平滑肌肉瘤。
结论
我们的病例表明，由于ETT罕见且组织学上与其他病理相似，其诊断具有挑战性。误诊会延误有效治疗并影响生存。在一项60年的文献调查中，迄今为止仅报道了8例既往无妊娠事件且人绒毛膜促性腺激素（β-HCG）水平正常的子宫ETT病例。
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