Department of Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Tianshan District, Urumqi, 830001, Xinjiang, China.
Institute of Clinical Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Tianshan District, Urumqi, 830001, Xinjiang, China.
Lipids Health Dis. 2021 Sep 25;20(1):116. doi: 10.1186/s12944-021-01544-3.
Dyslipidemia is a predisposing factor for coronary heart disease (CHD). High-intensity statin therapy is recommended as secondary prevention. ABCB1 and SLCO1B1 genes influence the efficacy and safety of statins. Xinjiang is a multi-ethnic area; however, little is known about the prevalence of dyslipidemia and gene polymorphisms of ABCB1 and SLCO1B1 in minority groups with CHD.
To measure levels of lipid and apolipoprotein and the prevalence of dyslipidemia and gene polymorphisms of ABCB1, SLCO1B1 in Han, Uygur, Kazak, Hui, Tatar, Kirgiz, and Sibe populations with CHD in Xinjiang.
This descriptive retrospective study compares lipid levels in ethnic groups using Kruskal-Wallis test or analysis of variance. The study compared gene polymorphisms and the prevalence of dyslipidemia among different ethnic groups using the chi-square test. The lipid profiles in plasma were measured before lipid-lowering therapy using commercially available kits. Genotyping of SLCO1B1 and ABCB1 variants was performed using sequencing by hybridization.
A total of 2218 patients were successfully screened, including 1044 Han, 828 Uygur, 113 Kazak, 138 Hui, 39 Tatar, 36 Kirgiz, and 20 Sibe patients. The overall mean age was 61.8 ± 10.8 years, and 72.5% of participants were male. Dyslipidemia prevalence in these ethnic groups was 42.1, 49.8, 52.2, 40.6, 48.7, 41.7, and 45.0%, respectively. The prevalence of dyslipidemia, high total cholesterol (TC), high triglycerides (TG), and high low density lipoprotein cholesterol (LDL-C) differed significantly among the groups (P = 0.024; P < 0.001; P < 0.001; P < 0.001, respectively). For the Han group, high LDL-C, high TC, and high TG prevalence differed significantly by gender (P = 0.001, P = 0.022, P = 0.037, respectively). The prevalence of high TC, high TG, and low high density lipoprotein cholesterol (HDL-C) differed significantly by gender in the Uygur group (P = 0.006, P = 0.004, P < 0.001, respectively). The prevalence of high TC in Hui patients significantly differed by gender (P = 0.043). These findings suggest that polymorphisms in ABCB1 and C3435T differ significantly across ethnicities (P < 0.001).
The prevalences of dyslipidemia, high TC, high TG, and high LDL-C in Han, Uygur, Kazak, Hui, Tatar, Kirgiz, and Sibe CHD patients in Xinjiang differed concerning ethnicity. Ethnic, gender, and lifestyle were the key factors that affected the lipid levels of the population. The prevalence of polymorphisms of ABCB1 and C3435T significantly differed across ethnicities. These findings will aid the selection of precision lipid-lowering medications and prevention and treatment of CHD according to ethnicity in Xinjiang.
血脂异常是冠心病（CHD）的一个致病因素。高强度他汀类药物治疗被推荐作为二级预防。ABCB1 和 SLCO1B1 基因影响他汀类药物的疗效和安全性。新疆是一个多民族地区，但对于少数民族 CHD 患者的血脂异常和 ABCB1、SLCO1B1 基因多态性的流行情况知之甚少。
测量汉族、维吾尔族、哈萨克族、回族、塔塔尔族、柯尔克孜族、蒙古族和锡伯族 CHD 患者的血脂和载脂蛋白水平以及血脂异常的流行情况，并检测 ABCB1 和 SLCO1B1 基因多态性。
本描述性回顾性研究使用 Kruskal-Wallis 检验或方差分析比较不同种族的血脂水平。采用卡方检验比较不同种族之间的基因多态性和血脂异常的流行情况。使用商业试剂盒在降脂治疗前测量血浆中的血脂谱。使用杂交测序对 SLCO1B1 和 ABCB1 变体的基因分型进行。
共成功筛选出 2218 例患者，包括 1044 例汉族、828 例维吾尔族、113 例哈萨克族、138 例回族、39 例塔塔尔族、36 例柯尔克孜族和 20 例锡伯族患者。这些患者的平均年龄为 61.8±10.8 岁，72.5%为男性。这些民族的血脂异常患病率分别为 42.1%、49.8%、52.2%、40.6%、48.7%、41.7%和 45.0%。各组之间血脂异常、高总胆固醇（TC）、高甘油三酯（TG）和低高密度脂蛋白胆固醇（LDL-C）的患病率差异有统计学意义（P=0.024；P<0.001；P<0.001；P<0.001）。汉族组中，高 LDL-C、高 TC 和高 TG 的患病率在性别间差异有统计学意义（P=0.001，P=0.022，P=0.037）。维吾尔族组中，高 TC、高 TG 和低高密度脂蛋白胆固醇（HDL-C）的患病率在性别间差异有统计学意义（P=0.006，P=0.004，P<0.001）。回族患者中高 TC 的患病率在性别间差异有统计学意义（P=0.043）。这些发现表明 ABCB1 和 C3435T 多态性在不同民族间存在显著差异（P<0.001）。
新疆汉族、维吾尔族、哈萨克族、回族、塔塔尔族、柯尔克孜族和蒙古族 CHD 患者血脂异常、高 TC、高 TG 和高 LDL-C 的患病率存在种族差异。种族、性别和生活方式是影响人群血脂水平的关键因素。ABCB1 和 C3435T 多态性的患病率在不同民族间存在显著差异。这些发现将有助于根据新疆的种族选择精准降脂药物，并预防和治疗 CHD。
