Licastro F, Walford R L
Gerontology. 1986;32(1):1-9. doi: 10.1159/000212759.
The effect of in vitro addition of indomethacin, an inhibitor of the cyclooxygenase pathway, and of prostaglandin E1 and E2 on the proliferative capacity of phytohemagglutinin- and concanavalin A-stimulated spleen lymphocytes from young and old, long-lived (C3H X C57BL/10 RIII)F1 mice was investigated. Mitogen-activated splenocytes from old mice showed a different sensitivity to these drugs than splenocytes from young animals. Additionally, our data indicate that drugs can act either as inhibitors or as stimulators of mitogenesis, depending on the mitogen used, the dose of the drug, the age of the cell donor and the length of time in culture. It is suggested that prostaglandins of the E series may play a role in the pathogenesis of age-associated immune impairment.
研究了体外添加环氧合酶途径抑制剂吲哚美辛以及前列腺素E1和E2对年轻和年老的长寿（C3H×C57BL/10 RIII）F1小鼠经植物血凝素和刀豆球蛋白A刺激的脾淋巴细胞增殖能力的影响。来自老年小鼠的丝裂原激活脾细胞对这些药物的敏感性与来自年轻动物的脾细胞不同。此外，我们的数据表明，药物可作为有丝分裂的抑制剂或刺激剂，这取决于所使用的丝裂原、药物剂量、细胞供体的年龄以及培养时间的长短。有人提出，E系列前列腺素可能在与年龄相关的免疫损伤发病机制中起作用。
