Miller S C
Department of Anatomy, McGill University, Montreal, P.Q., Canada.
Experientia. 1992 Jul 15;48(7):674-8. doi: 10.1007/BF02118317.
During 21 days of indomethacin treatment, erythroid cells in the spleens of both young adult and older mice, and in the bone marrow of young adult mice, were increased significantly early in treatment, relative to age-matched control organs, and remained high throughout treatment. During drug exposure, the numbers of myeloid cells in young adult bone marrow, but not spleen, were reduced, but in older mice these cells were elevated in both organs. Lymphoid cells in the young adult and older mouse spleens decreased and increased, respectively, during treatment, but were unchanged and decreased, respectively, in the bone marrow of young adult and older mice. Monocyte-macrophage cells in the spleen were elevated but unchanged in the bone marrow of both age groups. During 14 days of indomethacin treatment of young adult mice, the proportions of precursor cells in DNA synthesis of only the splenic erythroid lineage were increased. Thus, the major hemopoietic lineages in both the bone marrow and spleen are affected by exposure to indomethacin in a time-dependent and age-dependent manner. For all lineages studied, those of the bone marrow were least disturbed and/or were first to recover, even during continued drug exposure.
在吲哚美辛治疗的21天里，与年龄匹配的对照器官相比，年轻成年小鼠和老年小鼠脾脏中的红系细胞以及年轻成年小鼠骨髓中的红系细胞在治疗早期显著增加，并在整个治疗过程中保持高位。在药物暴露期间，年轻成年小鼠骨髓而非脾脏中的髓系细胞数量减少，但在老年小鼠中，这些细胞在两个器官中均升高。年轻成年小鼠和老年小鼠脾脏中的淋巴细胞在治疗期间分别减少和增加，但在年轻成年小鼠和老年小鼠的骨髓中分别保持不变和减少。两个年龄组脾脏中的单核细胞-巨噬细胞数量均升高，但骨髓中的数量未变。在对年轻成年小鼠进行14天的吲哚美辛治疗期间，仅脾脏红系谱系中处于DNA合成阶段的前体细胞比例增加。因此，骨髓和脾脏中的主要造血谱系受到吲哚美辛暴露的影响，呈现出时间依赖性和年龄依赖性。对于所有研究的谱系，即使在持续药物暴露期间，骨髓中的谱系受干扰最小和/或最先恢复。
