Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Human Immunology and Immunopathology, Inserm UMR 976, Paris, France; Université de Paris, Paris, France.
Cytokine. 2021 Dec;148:155705. doi: 10.1016/j.cyto.2021.155705. Epub 2021 Sep 24.
Cytokines, soluble mediators of the immune system, play a critical role in the pathogenesis of autoimmune, allergic and infectious diseases. They are also implicated in the initiation and development of allograft rejection. During recent years, there have been considerable advances in generating novel anti-cytokine agents with promoted efficacy and safety, which could be administrated for managing dysregulated cytokine secretion; besides, gene therapy for overexpression of immunomodulatory cytokines has shown substantial improvements. Liver transplantation has been established as a life-saving treatment for end-stage hepatic diseases but the growing number of recipients urge for improved post-transplant care including tolerance induction, infection control and resolving immunosuppressant drugs adverse effects. Cytokines with a wide range of proinflammatory and regulatory properties might be considered as potential therapeutic targets for selective suppression or enhancement of the immune responses in recipients. In the present review, we aimed to summarize the positive and negative effects of cytokines on liver allograft in addition to their prognostic and therapeutic values.
细胞因子是免疫系统的可溶性介质，在自身免疫、过敏和传染病的发病机制中起着关键作用。它们也与同种异体移植物排斥的启动和发展有关。近年来，人们在生成具有更高疗效和安全性的新型抗细胞因子药物方面取得了相当大的进展，这些药物可用于调节失调的细胞因子分泌；此外，免疫调节细胞因子的过表达基因治疗也取得了显著的改善。肝移植已成为治疗终末期肝病的救命疗法，但越来越多的受者需要改善移植后的护理，包括诱导耐受、控制感染和解决免疫抑制剂药物的不良反应。具有广泛促炎和调节特性的细胞因子可能被认为是选择性抑制或增强受者免疫反应的潜在治疗靶点。在本综述中，我们旨在总结细胞因子对肝移植的积极和消极影响，以及它们的预后和治疗价值。
