Zakrzewska J M, Nally F F, Flint S R
J Maxillofac Surg. 1986 Feb;14(1):5-7. doi: 10.1016/s0301-0503(86)80248-x.
Paroxysmal trigeminal neuralgia still remains a difficult condition to treat. Carbamazepine (Tegretol) has been a first line treatment, failing this surgery becomes necessary. However, many surgical procedures result in permanent sensory loss. Peripheral cryotherapy, along with the recently described Jannetta (1976) and Hakanson (1981) techniques, attempt to preserve sensation. Cryotherapy to 53 branches of the trigeminal nerve in 39 patients, who were followed up for 4 years, resulted in pain relief out-lasting return of sensation. These cases show that cryotherapy applied to the correctly located affected nerve branches can produce results which are unobtainable by other methods of pain control in paroxysmal trigeminal neuralgia.
阵发性三叉神经痛仍然是一种难以治疗的病症。卡马西平（痛痉宁）一直是一线治疗药物，若治疗失败则手术成为必要手段。然而，许多外科手术会导致永久性感觉丧失。外周冷冻疗法，以及最近描述的詹内塔（1976年）和哈坎松（1981年）技术，试图保留感觉功能。对39例患者的53支三叉神经分支进行冷冻治疗，并随访4年，结果疼痛缓解持续时间超过感觉恢复时间。这些病例表明，对正确定位的受影响神经分支应用冷冻疗法可产生阵发性三叉神经痛其他疼痛控制方法无法获得的效果。
