Antoniak Klaudia, Hansdorfer-Korzon Rita, Mrugacz Małgorzata, Zorena Katarzyna
Department of Immunobiology and Environment Microbiology, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, Poland.
Department of Physical Therapy, Medical University of Gdańsk, Dębinki 7, 80-211 Gdańsk, Poland.
Metabolites. 2021 Sep 11;11(9):617. doi: 10.3390/metabo11090617.
The World Health Organization (WHO) has recognised obesity as one of the top ten threats to human health. Obesity is not only a state of abnormally increased adipose tissue in the body, but also of an increased release of biologically active metabolites. Moreover, obesity predisposes the development of metabolic syndrome and increases the incidence of type 2 diabetes (T2DM), increases the risk of developing insulin resistance, atherosclerosis, ischemic heart disease, polycystic ovary syndrome, hypertension and cancer. The lymphatic system is a one-directional network of thin-walled capillaries and larger vessels covered by a continuous layer of endothelial cells that provides a unidirectional conduit to return filtered arterial and tissue metabolites towards the venous circulation. Recent studies have shown that obesity can markedly impair lymphatic function. Conversely, dysfunction in the lymphatic system may also be involved in the pathogenesis of obesity. This review highlights the important findings regarding obesity related to lymphatic system dysfunction, including clinical implications and experimental studies. Moreover, we present the role of biological factors in the pathophysiology of the lymphatic system and we propose the possibility of a therapy supporting the function of the lymphatic system in the course of obesity.
世界卫生组织（WHO）已将肥胖认定为对人类健康的十大威胁之一。肥胖不仅是体内脂肪组织异常增加的一种状态，也是生物活性代谢产物释放增加的状态。此外，肥胖易引发代谢综合征，增加2型糖尿病（T2DM）的发病率，增加胰岛素抵抗、动脉粥样硬化、缺血性心脏病、多囊卵巢综合征、高血压和癌症的发病风险。淋巴系统是一个由薄壁毛细血管和较大血管组成的单向网络，其表面覆盖着一层连续的内皮细胞，为将过滤后的动脉和组织代谢产物返回静脉循环提供单向管道。最近的研究表明，肥胖会显著损害淋巴功能。相反，淋巴系统功能障碍也可能参与肥胖的发病机制。本综述重点介绍了与淋巴系统功能障碍相关的肥胖的重要研究发现，包括临床意义和实验研究。此外，我们阐述了生物因素在淋巴系统病理生理学中的作用，并提出了在肥胖过程中支持淋巴系统功能的治疗可能性。
