Burian Martin, Hajek Milan, Sedivy Petr, Mikova Irena, Trunecka Pavel, Dezortova Monika
MR-Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.
Department of Hepatogastroenterology, Institute for Clinical and Experimental Medicine, 140 21 Prague, Czech Republic.
Metabolites. 2021 Sep 15;11(9):625. doi: 10.3390/metabo11090625.
Increased hepatic fat content (HFC) is a hallmark of non-alcoholic fatty liver (NAFL) disease, a common condition in liver transplant recipients. Proton MR spectroscopy (H MRS) and MR imaging-based proton density fat fraction as the only diagnosis modality enable precise non-invasive measurement of HFC and, also, fatty acid profiles in vivo. Using H MRS at 3T, we examined 47 liver transplantation candidates and 101 liver graft recipients. A point-resolved spectroscopy sequence was used to calculate the steatosis grade along with the saturated, unsaturated and polyunsaturated fractions of fatty acids in the liver. The steatosis grade measured by MRS was compared with the histological steatosis grade. HFC, represented by fat fraction values, is adept at distinguishing non-alcoholic steatohepatitis (NASH), NAFL and non-steatotic liver transplant patients. Relative hepatic lipid saturation increases while unsaturation decreases in response to increased HFC. Additionally, relative hepatic lipid saturation increases while unsaturation and polyunsaturation both decrease in liver recipients with histologically proven post-transplant NASH or NAFL compared to non-steatotic patients. HFC, measured by in vivo H MRS, correlated well with histological results. H MRS is a simple and fast method for in vivo analysis of HFC and its composition. It provides non-invasive support for NAFL and NASH diagnoses.
肝脏脂肪含量（HFC）增加是非酒精性脂肪性肝病（NAFL）的一个标志，这在肝移植受者中是一种常见情况。质子磁共振波谱（H MRS）以及基于磁共振成像的质子密度脂肪分数作为仅有的诊断方式，能够在体内精确地非侵入性测量HFC以及脂肪酸谱。我们使用3T的H MRS对47例肝移植候选者和101例肝移植受者进行了检查。采用点分辨波谱序列来计算肝脏的脂肪变性分级以及脂肪酸的饱和、不饱和和多不饱和分数。将通过MRS测量的脂肪变性分级与组织学脂肪变性分级进行比较。以脂肪分数值表示的HFC能够很好地区分非酒精性脂肪性肝炎（NASH）、NAFL和非脂肪变性的肝移植患者。随着HFC增加，肝脏脂质相对饱和度升高，而不饱和度降低。此外，与非脂肪变性患者相比，在组织学证实有移植后NASH或NAFL的肝移植受者中，肝脏脂质相对饱和度升高，而不饱和度和多不饱和度均降低。通过体内H MRS测量的HFC与组织学结果相关性良好。H MRS是一种用于体内分析HFC及其组成的简单快速方法。它为NAFL和NASH诊断提供非侵入性支持。
