Department of Veterinary Prevention and Feed Hygiene, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13/29, 10-718 Olsztyn, Poland.
Department of Internal Diseases with Clinic, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, 10-718 Olsztyn, Poland.
Toxins (Basel). 2021 Sep 6;13(9):625. doi: 10.3390/toxins13090625.
Vascular toxicity induced by xenobiotics is associated with dysfunctions or damage to endothelial cells, changes in vascular permeability or dysregulation of the vascular redox state. The aim of this study was to determine whether per os administration of zearalenone (ZEN) influences selected hemostatic parameters in prepubertal gilts. This study was performed on female gilts divided into a control group which received placebo and an experimental group which received ZEN at a dose of 5.0 µg·kg b.w. × day. On days 14, 28 and 42, blood samples were collected from the animals for analyses of hematological, coagulation and fibrinolysis parameters, nitric oxide, von Willebrand factor antigen content and catalase activity. The results demonstrated that the treatment of gilts with ZEN at a dose below no observable adverse effect level did not affect the primary hemostasis and the blood coagulation cascade. However, ZEN could have temporarily affected the selected indicators of endothelial cell function (increase of von Willebrand factor, decrease of nitric oxide levels) and the oxidative status plasma (decrease of catalase activity) of the exposed gilts. In summary, these results suggest that the adaptive response to ZEN-exposure can induce a transient imbalance in the vascular system by acting on vascular endothelial cells.
外源性物质引起的血管毒性与内皮细胞功能障碍或损伤、血管通透性改变或血管氧化还原状态失调有关。本研究旨在确定经口给予玉米赤霉烯酮（ZEN）是否会影响未成年母猪的某些止血参数。本研究在雌性仔猪中进行，分为对照组（给予安慰剂）和实验组（给予 ZEN，剂量为 5.0µg·kg b.w.×天）。在第 14、28 和 42 天，从动物身上采集血液样本，用于分析血液学、凝血和纤溶参数、一氧化氮、血管性血友病因子抗原含量和过氧化氢酶活性。结果表明，以低于无可见不良反应水平的剂量给仔猪施用 ZEN 不会影响初级止血和凝血级联反应。然而，ZEN 可能暂时影响了暴露仔猪的内皮细胞功能的某些选定指标（血管性血友病因子增加，一氧化氮水平降低）和血浆氧化状态（过氧化氢酶活性降低）。总之，这些结果表明，对外源性物质暴露的适应性反应可能通过作用于血管内皮细胞，导致血管系统短暂失衡。
