Schmidt J A, Marshall J, Hayman M J, Doderlein G, Beug H
Leuk Res. 1986;10(3):257-72. doi: 10.1016/0145-2126(86)90023-8.
A panel of new monoclonal antibodies to antigens on the surface of chick erythroid progenitor cells is described. These are characterised with respect to their binding to different classes of normal haemopoietic cells of both the erythroid and myeloid lineages. Using these antibodies, we have examined the phenotype of avian leukaemic cells transformed by retroviruses carrying defined oncogenes. Our data show that these cells, although similar to the normal haematopoietic precursor from which they are derived, aberrantly express certain markers in an oncogene specific manner.
本文描述了一组针对鸡红细胞祖细胞表面抗原的新型单克隆抗体。这些抗体的特征在于它们与红系和髓系谱系的不同类别的正常造血细胞的结合情况。利用这些抗体，我们检测了携带特定癌基因的逆转录病毒转化的禽类白血病细胞的表型。我们的数据表明，这些细胞虽然与它们所源自的正常造血前体细胞相似，但却以癌基因特异性的方式异常表达某些标志物。
