Department of Internal Medicine-Geriatrics, 12338University of Texas Medical Branch, Galveston, TX, USA.
Sealy Center on Aging, 12338University of Texas Medical Branch, Galveston, TX, USA.
Am J Alzheimers Dis Other Demen. 2021 Jan-Dec;36:15333175211042958. doi: 10.1177/15333175211042958.
Background and ObjectivesTo assess gender differences in prevalence of neuropsychiatric symptoms (NPS) among community-dwelling Mexican Americans ≥80 years. Using data from Wave 7 (2010-2011) of the Hispanic Established Population for the Epidemiological Study of the Elderly, we analyzed the NPS of 914 participants as determined by the Neuropsychiatric Inventory (NPI) with assessments conducted by their caregivers. Multivariate logistic regression models were used to test the association of individual NPS with gender, adjusting for relevant characteristics. The average age of our sample was 86.1 years, and 65.3% were women. Over 60% of participants had at least one informant/caregiver reported NPS. After adjustment, women had lower odds than men of agitation/aggression but higher odds of dysphoria/depression and anxiety. Recognizing gender differences in NPS phenotype could help guide development of culturally appropriate NPS screening and treatment programs.
评估 80 岁及以上的墨西哥裔美国社区居民中神经精神症状（NPS）的患病率存在性别差异。本研究使用西班牙裔老年人流行病学研究中的既定人口队列研究的第 7 波（2010-2011 年）的数据，通过其照顾者进行评估，用神经精神问卷（NPI）分析了 914 名参与者的 NPS。采用多变量逻辑回归模型，调整了相关特征后，检验了个体 NPS 与性别之间的关联。我们样本的平均年龄为 86.1 岁，65.3%为女性。超过 60%的参与者至少有一位知情者/照顾者报告存在 NPS。调整后，女性发生激越/攻击的可能性低于男性，但发生抑郁/沮丧和焦虑的可能性高于男性。认识到 NPS 表型存在性别差异，可以帮助指导制定文化适宜的 NPS 筛查和治疗方案。
