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有氧运动训练可预防高蔗糖饮食喂养的大鼠的肾功能参数和身体成分损伤。

Aerobic exercise training prevents impairment in renal parameters and in body composition of rats fed a high sucrose diet.

机构信息

Dept. of Pharmacology, ICB, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

Physical Education School, Federal University of Ouro Preto (UFOP), Ouro Preto, MG, 35,400-000, Brazil.

出版信息

BMC Res Notes. 2021 Sep 26;14(1):378. doi: 10.1186/s13104-021-05790-7.

Abstract

OBJECTIVE

This study aimed to evaluate the effect of swimming training (T) on the renal system and body composition parameters in young animals treated with a high sucrose diet (SUD) during 12 weeks.

RESULTS

The SUD impaired the physical performance, increased the body adiposity index (BAI), Lee index (LI) and retroperitoneal adipose tissue (RAT) weight, plasma creatinine and number renal cells nuclei, decreased urinary volume and urinary creatinine excretion besides creatinine clearance. The T reversed the increased the BAI, LI, RAT weight, plasma and urinary creatinine, creatinine clearance and number renal cells nuclei in addition to promoting decrease in urinary protein excretion. This study found that eight weeks of swimming physical training protected renal function and restored normal glomerular filtration rate (GFR) values. Swimming training also contributed to prevention of the onset of a renal inflammatory process and caused a decrease in the risk of development of obesity promoted by SUD decreasing the body composition parameters (BAI, LI, and RAT weight).

摘要

目的

本研究旨在评估游泳训练(T)对接受高蔗糖饮食(SUD)治疗的年轻动物的肾脏系统和身体成分参数的影响,为期 12 周。

结果

SUD 降低了动物的身体机能表现,增加了体脂指数(BAI)、Lee 指数(LI)和腹膜后脂肪组织(RAT)重量、血浆肌酐和肾脏细胞核数量,同时降低了尿体积和尿肌酐排泄,以及肌酐清除率。T 则逆转了 SUD 引起的 BAI、LI、RAT 重量、血浆和尿肌酐、肌酐清除率和肾脏细胞核数量的增加,并促进了尿蛋白排泄的减少。本研究发现,八周的游泳体能训练可保护肾功能并恢复正常的肾小球滤过率(GFR)值。游泳训练还可预防 SUD 引起的肥胖所导致的肾脏炎症过程的发生,并降低肥胖风险,从而降低身体成分参数(BAI、LI 和 RAT 重量)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0ae/8474763/5f1da9e92384/13104_2021_5790_Fig1_HTML.jpg

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