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制定新疫苗战略的路线图。

Charting a Course toward a New Vaccine Strategy.

作者信息

Nadal Gerard M

机构信息

The Coalition on Abortion/Breast Cancer, Staten Island, NY, USA.

出版信息

Linacre Q. 2021 Aug;88(3):247-253. doi: 10.1177/00243639211014621. Epub 2021 May 28.

DOI:10.1177/00243639211014621
PMID:34565899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8375380/
Abstract

There has been a long-simmering disquiet in Catholic circles regarding the use cell lines derived from aborted fetal tissue. This concern has exploded into the public consciousness given the use of questionable cell lines in the development and/or testing of the current COVID-19 vaccines, and the debate within the Church over the permissibility of using these vaccines. The history of cell culture and how the biological community came to rely on HEK293 fetal cell lines is explored, as is the way forward, moving the biotech industry away from ethically problematic cells and toward the development of more ethically sourced cell lines. The role of the Church in leading the way forward and the acceptable use of medicines utilizing HEK293 cell lines are all explored.

摘要

在天主教圈子里,对于使用源自堕胎胎儿组织的细胞系一直存在着长期潜伏的不安情绪。鉴于当前新冠疫苗的研发和/或测试中使用了存在问题的细胞系,以及教会内部关于使用这些疫苗是否可允许的辩论,这种担忧已迅速进入公众意识。本文探讨了细胞培养的历史以及生物科学界如何开始依赖人胚肾293(HEK293)胎儿细胞系,还探讨了未来的发展方向,即推动生物技术产业摆脱有伦理问题的细胞,转而开发来源更符合伦理的细胞系。文中还探讨了教会在引领前进道路方面的作用以及使用利用HEK293细胞系的药物的可接受性。

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1
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2
Use of Aborted Fetal Tissue in Vaccines and Medical Research Obscures the Value of All Human Life.在疫苗和医学研究中使用流产胎儿组织掩盖了所有人生命的价值。
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[Religion, morality and politics: the abortion debate].[宗教、道德与政治:堕胎辩论]
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本文引用的文献

1
Bioethics, Conscience, and Prudence in the Time of COVID.新冠疫情下的生物伦理学、良知与审慎
Linacre Q. 2021 May;88(2):112-113. doi: 10.1177/0024363921991262. Epub 2021 Feb 5.
2
Post-acute COVID-19 syndrome.新冠病毒感染后长期综合征。
Nat Med. 2021 Apr;27(4):601-615. doi: 10.1038/s41591-021-01283-z. Epub 2021 Mar 22.
3
SARS, MERS and COVID-19: clinical manifestations and organ-system complications: a mini review.严重急性呼吸综合征(SARS)、中东呼吸综合征(MERS)和新型冠状病毒肺炎(COVID-19):临床表现和器官系统并发症:一篇小型综述。
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mRNA vaccines - a new era in vaccinology.mRNA 疫苗——疫苗学的新纪元。
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Advancements in reprogramming strategies for the generation of induced pluripotent stem cells.重编程策略在诱导多能干细胞生成中的进展。
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A statement by the editors of The Lancet.《柳叶刀》编辑的一份声明。
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The serial cultivation of human diploid cell strains.人二倍体细胞株的连续培养。
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Genetical implications of the structure of deoxyribonucleic acid.脱氧核糖核酸结构的遗传学意义。
Nature. 1953 May 30;171(4361):964-7. doi: 10.1038/171964b0.
9
Independent functions of viral protein and nucleic acid in growth of bacteriophage.病毒蛋白和核酸在噬菌体生长中的独立功能。
J Gen Physiol. 1952 May;36(1):39-56. doi: 10.1085/jgp.36.1.39.
10
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children.儿童回肠淋巴小结增生、非特异性结肠炎与广泛性发育障碍
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