人衰老红细胞与自体单核细胞的黏附及红细胞吞噬作用，以及β-半乳糖基衍生物对其的抑制作用。
Adhesion and erythrophagocytosis of human senescent erythrocytes by autologous monocytes and their inhibition by beta-galactosyl derivatives.
作者信息
Vaysse J, Gattegno L, Bladier D, Aminoff D
出版信息
Proc Natl Acad Sci U S A. 1986 Mar;83(5):1339-43. doi: 10.1073/pnas.83.5.1339.
Abstract
Senescent human erythrocytes (RBC) are able to adhere to and be phagocytized by autologous monocytes in vitro to a greater extent than are young RBC. This adhesion and erythrophagocytosis of senescent RBC is inhibited by D-galactose, N-acetyl-D-galactosamine, their corresponding derivatives of bovine serum albumin, and lactose. On the other hand, D-glucose, D-mannose, L-fucose, N-acetyl-D-glucosamine, and their corresponding derivatives of bovine serum albumin are noninhibiting. The glycopeptides released by tryptic digestion of senescent RBC and purified on immobilized peanut agglutinin are the most effective inhibitors of both RBC adhesion and phagocytosis by autologous monocytes obtained from peripheral blood.
摘要
衰老的人类红细胞（RBC）在体外比年轻红细胞更能黏附于自体单核细胞并被其吞噬。衰老红细胞的这种黏附和红细胞吞噬作用受到D-半乳糖、N-乙酰-D-半乳糖胺、它们相应的牛血清白蛋白衍生物以及乳糖的抑制。另一方面，D-葡萄糖、D-甘露糖、L-岩藻糖、N-乙酰-D-葡糖胺以及它们相应的牛血清白蛋白衍生物则没有抑制作用。通过胰蛋白酶消化衰老红细胞并在固定化花生凝集素上纯化得到的糖肽，是外周血来源的自体单核细胞对红细胞黏附和吞噬作用最有效的抑制剂。
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