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社区环境下剖宫产脊髓麻醉中鞘内使用芬太尼的发生率及效果:一项单中心观察性回顾性研究

Incidence and Effect of Intrathecal Fentanyl Use in Spinal Anesthesia for Cesarean Deliveries in the Community Setting: A Single-Center Observational Retrospective Study.

作者信息

Brewer Autumn, Joseph Sarah, Hammonds Kendall, Hofkamp Michael P

机构信息

Texas A&M University Health Science Center College of Medicine, Temple, TX.

Office of Biostatistics, Baylor Scott & White Research Institute, Temple, TX.

出版信息

Ochsner J. 2021 Fall;21(3):267-271. doi: 10.31486/toj.20.0147.

DOI:10.31486/toj.20.0147
PMID:34566508
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8442207/
Abstract

The addition of intrathecal fentanyl to spinal anesthesia for cesarean delivery has been shown to be beneficial, but its rate of utilization in the community setting is unknown. The primary aim of our study was to determine the rate of intrathecal fentanyl use for cesarean deliveries with spinal anesthesia in a community hospital, and our secondary aim was to determine its effect on anesthetic outcomes. Patients who underwent cesarean delivery from June 1, 2017 to November 30, 2019 with spinal anesthesia as the initial anesthetic technique were included. Seven hundred sixty-one cesarean deliveries met inclusion criteria, and 161 (21.2%) patients received intrathecal fentanyl in their spinal anesthetic for cesarean delivery. A multivariate model that controlled for patient weight and time from spinal placement to procedure end showed that patients who received intrathecal fentanyl were less likely to have conversion to general anesthesia or administration of systemic anesthetic adjuncts compared to patients who did not receive intrathecal fentanyl (odds ratio 2.889, 95% CI 1.552-5.903; =0.0017). Only 1 in 5 patients received intrathecal fentanyl for cesarean deliveries performed under spinal anesthesia in a community hospital despite known benefits. Patients who did not receive intrathecal fentanyl had increased odds of conversion to general anesthesia or administration of systemic anesthetic adjunct administration, a finding consistent with previous studies. The addition of intrathecal fentanyl to spinal anesthesia for cesarean delivery should be strongly considered in the community setting.

摘要

剖宫产脊髓麻醉时添加鞘内注射芬太尼已被证明是有益的,但在社区环境中的使用率尚不清楚。我们研究的主要目的是确定社区医院剖宫产脊髓麻醉时鞘内注射芬太尼的使用率,次要目的是确定其对麻醉效果的影响。纳入2017年6月1日至2019年11月30日以脊髓麻醉作为初始麻醉技术进行剖宫产的患者。761例剖宫产符合纳入标准,161例(21.2%)患者在剖宫产脊髓麻醉时接受了鞘内注射芬太尼。一个控制患者体重以及从脊髓置管到手术结束时间的多变量模型显示,与未接受鞘内注射芬太尼的患者相比,接受鞘内注射芬太尼的患者转为全身麻醉或使用全身麻醉辅助药物的可能性较小(比值比2.889,95%可信区间1.552 - 5.903;P = 0.0017)。尽管已知有好处,但在社区医院剖宫产脊髓麻醉时,每5例患者中只有1例接受鞘内注射芬太尼。未接受鞘内注射芬太尼的患者转为全身麻醉或使用全身麻醉辅助药物的几率增加,这一发现与先前的研究一致。在社区环境中,应强烈考虑在剖宫产脊髓麻醉时添加鞘内注射芬太尼。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c57/8442207/14c4de455f8e/toj-20-0147-figure1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c57/8442207/14c4de455f8e/toj-20-0147-figure1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c57/8442207/14c4de455f8e/toj-20-0147-figure1.jpg

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2
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BMC Anesthesiol. 2019 Oct 22;19(1):189. doi: 10.1186/s12871-019-0865-9.
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Efficacy of Intrathecal Fentanyl for Cesarean Delivery: A Systematic Review and Meta-analysis of Randomized Controlled Trials With Trial Sequential Analysis.
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