Li Nan, Li Xu, Yang Ping, Liu Hongbin, Kong Lingyu, Yu Xiaomeng
Pharmaceutical Analysis Center of Tianjin Institute of Medical and Pharmaceutical Sciences, 79 Duolun Road, Heping District, Tianjin 300020, China.
Cardiovascular and Cerebrovascular Drugs Research and Development Center of Tianjin Institute of Medical and Pharmaceutical Sciences, 79 Duolun Road,Heping District, Tianjin 300020, China.
Bioinorg Chem Appl. 2021 Sep 15;2021:5840852. doi: 10.1155/2021/5840852. eCollection 2021.
The development of spray drying technology has been widely used for drying and preservation of food products. Though infant milk powder iron fortification is necessary for infants and children, iron fortification is accompanied by some limitations that reduce its quality and oxidation of Fe2+ into Fe3+, causing sensory problems and even a decrease in iron absorption, which does not meet the normal requirements of infant and child body development. To overcome this adverse effect and to improve the bioavailability of iron, a spray drying method was used to simulate the milk powder production process by codrying a mixture of ascorbic acid and ferrous sulfate, where ascorbic acid was uniformly coated on the outer layer of ferrous sulfate. It was demonstrated that ascorbic acid had a very obvious inhibitory effect on the oxidation of ferrous iron and could maintain the stability of ferrous iron in solid and solution for a long time, thus improving the bioavailability of iron.
喷雾干燥技术的发展已广泛应用于食品的干燥和保存。虽然婴幼儿奶粉的铁强化对婴幼儿来说是必要的，但铁强化存在一些局限性，会降低其品质，使Fe2+氧化为Fe3+，导致感官问题，甚至铁吸收减少，这不符合婴幼儿身体发育的正常需求。为克服这种不利影响并提高铁的生物利用度，采用喷雾干燥法，通过将抗坏血酸和硫酸亚铁的混合物共干燥来模拟奶粉生产过程，其中抗坏血酸均匀包覆在硫酸亚铁外层。结果表明，抗坏血酸对亚铁的氧化有非常明显的抑制作用，能长时间保持亚铁在固体和溶液中的稳定性，从而提高铁的生物利用度。
