Hajifathaliha Fariba, Mahboubi Arash, Bolourchian Noushin, Mohit Elham, Nematollahi Leila
Food Safety Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Iran J Pharm Res. 2021 Spring;20(2):173-182. doi: 10.22037/ijpr.2020.114096.14660.
Since 1980 after introducing the concept of live cell encapsulation by Lim , this technology has received enormous attention. Several studies have been conducted to improve this technique; different polymers, either natural or synthetic, have been used as microcapsules` making materials and different substances as coating layers. Literature review leads us to the conclusion that alginate (Alg) multilayer microcapsules and, in particular, alginate-poly l-lysine (PLL)-alginate (APA) are the most used structures for live cell encapsulation. Although, disadvantages of PLL (., weak mechanical strength and low biocompatibility) made researchers work on other cationic polymers to find an alternative. This review aims to discuss more popularly suggested cationic polymers such as poly l-ornithine (PLO), chitosan, . As alternatives for PLL and, more importantly, we want to take a closer look to see which one of these systems are closer to clinical applications.
自1980年Lim引入活细胞包封概念后，这项技术受到了极大关注。人们进行了多项研究来改进该技术；天然或合成的不同聚合物被用作微胶囊的制造材料，不同物质被用作包衣层。文献综述使我们得出结论，藻酸盐（Alg）多层微胶囊，尤其是藻酸盐-聚-L-赖氨酸（PLL）-藻酸盐（APA）是活细胞包封中最常用的结构。然而，PLL的缺点（如机械强度弱和生物相容性低）促使研究人员研究其他阳离子聚合物以寻找替代物。本综述旨在更广泛地讨论如聚-L-鸟氨酸（PLO）、壳聚糖等更常被提及的阳离子聚合物。作为PLL的替代品，更重要的是，我们想更仔细地研究这些系统中哪一个更接近临床应用。
