同位素和非同位素载体对M3 + -柠檬酸盐络合物生物分布和生物动力学的影响。
The influence of isotopic and nonisotopic carriers on the biodistribution and biokinetics of M3+-citrate complexes.
作者信息
Schomäcker K, Franke W G, Henke E, Fromm W D, Maka G, Beyer G J
出版信息
Eur J Nucl Med. 1986;11(9):345-9. doi: 10.1007/BF00253299.
The influence of carrier amounts of Fe, Ga, and Tm on the biodistribution of 67Ga-, 59Fe-, and 167Tm-citrate in mice was investigated. Our results suggest that 167Tm, unlike 67Ga and 59Fe, is not transported by transferrin in the blood. Of the three radioisotopes tested, 167Tm had the highest tumor/background ratio (10 h after the injection). The application of Fe carrier led to an enhancement of the elimination of 67Ga from the blood and muscles, resulting in a better tumor/background ratio.
研究了铁、镓和铥载体量对67Ga-、59Fe-和167Tm-柠檬酸盐在小鼠体内生物分布的影响。我们的结果表明，与67Ga和59Fe不同，167Tm在血液中不是由转铁蛋白转运的。在所测试的三种放射性同位素中，167Tm具有最高的肿瘤/本底比值（注射后10小时）。铁载体的应用导致67Ga从血液和肌肉中的清除增强，从而产生更好的肿瘤/本底比值。
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