人骨肉瘤细胞系U-2 OS表达一种3.8千碱基的信使核糖核酸，该信使核糖核酸编码血小板源性生长因子-B链的序列。
The human osteosarcoma cell line U-2 OS expresses a 3.8 kilobase mRNA which codes for the sequence of the PDGF-B chain.
作者信息
Weich H A, Sebald W, Schairer H U, Hoppe J
出版信息
FEBS Lett. 1986 Mar 31;198(2):344-8. doi: 10.1016/0014-5793(86)80433-1.
PMID:3456904
Abstract
A cDNA clone of about 2500 base pairs was prepared from the human osteosarcoma cell line U-2 OS by hybridizing with a v-sis probe. Sequence analysis showed that this cDNA contains the coding region for the PDGF-B chain. It is discussed that the mitogen secreted by these osteosarcoma cells contains the PDGF-B chain and is probably a homodimer of two B-chains.
摘要
通过与v-sis探针杂交，从人骨肉瘤细胞系U-2 OS制备了一个约2500个碱基对的cDNA克隆。序列分析表明，该cDNA包含血小板源性生长因子-B链（PDGF-B链）的编码区。据讨论，这些骨肉瘤细胞分泌的促有丝分裂原含有PDGF-B链，可能是两条B链的同二聚体。
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