Grimm H
Infection. 1986;14 Suppl 1:S16-9. doi: 10.1007/BF01645192.
Regression analyses to determine the correlation of MIC and inhibition zone produced by ofloxacin disks were carried out using 300 freshly isolated cultures of infective organisms (20 strains each from 15 species). It was found in pilot studies that the correlation becomes poorer with increasing disk loads. Disks containing 5 micrograms of ofloxacin were chosen for comparative studies using Mueller-Hinton agar and Kirby-Bauer, as well as DIN-58940 methods. Based on preliminary MIC breakpoints of 1 and 4 mg/l and on calculations from regression equations, the following zone interpretations using the Kirby-Bauer method are recommended: resistant = up to 12 mm, intermediate = 13 to 19 mm, susceptible = 20 mm or more. The respective values for the DIN method are: resistant = up to 14 mm, intermediate = 15 to 21 mm, susceptible = 22 mm or more. The results are similar to those obtained by us in previous studies with norfloxacin, enoxacin and ciprofloxacin.
利用300株新分离的感染性生物体培养物（来自15个物种，每个物种20株）进行回归分析，以确定氧氟沙星纸片产生的最低抑菌浓度（MIC）与抑菌圈的相关性。在预试验中发现，随着纸片含药量增加，相关性变差。选用含5微克氧氟沙星的纸片，采用穆勒-欣顿琼脂和柯氏-鲍氏法以及德国标准DIN-58940方法进行对比研究。根据1毫克/升和4毫克/升的初步MIC断点以及回归方程计算结果，推荐使用柯氏-鲍氏法进行如下抑菌圈判读：耐药=直径达12毫米，中介=13至19毫米，敏感=20毫米或更大。DIN法的相应数值为：耐药=直径达14毫米，中介=15至21毫米，敏感=22毫米或更大。这些结果与我们之前使用诺氟沙星、依诺沙星和环丙沙星所获得的结果相似。
