Grimm H
Infection. 1986;14 Suppl 3:S191-5. doi: 10.1007/BF01667842.
Studies of cross resistance between norfloxacin, ofloxacin, enoxacin and ciprofloxacin using 599 strains of non-fermentative gram-negative rods (297 Pseudomonas spp. and 302 Acinetobacter spp.) resulted in nearly identical minimal inhibitory concentrations of norfloxacin and enoxacin Comparing MIC values, in most ofloxacin was one to four dilution steps superior to enoxacin, and ciprofloxacin was one to four dilution steps superior to ofloxacin. There was not much difference in MICs when species were studied in more detail. In some instances susceptibility testing with more than one new quinolone may be necessary, and evaluation criteria are given.
利用599株非发酵革兰氏阴性杆菌（297株假单胞菌属和302株不动杆菌属）对诺氟沙星、氧氟沙星、依诺沙星和环丙沙星之间的交叉耐药性进行研究，结果显示诺氟沙星和依诺沙星的最低抑菌浓度几乎相同。比较最低抑菌浓度值，在大多数情况下，氧氟沙星比依诺沙星高1至4个稀释度，环丙沙星比氧氟沙星高1至4个稀释度。当对菌种进行更详细的研究时，最低抑菌浓度没有太大差异。在某些情况下，可能需要用一种以上的新型喹诺酮进行药敏试验，并给出了评估标准。
