Department of Medical Oncology, 64001Gazi University Faculty of Medicine, Ankara, Turkey.
J Oncol Pharm Pract. 2022 Mar;28(2):486-488. doi: 10.1177/10781552211040725. Epub 2021 Sep 27.
Acute pancreatitis associated with Pazopanib has been reported in the literature. Bitter Melon (Momordica Charantia) is traditionally used as a folk medicine in many regions. In this report, we describe a 65-year-old patient with a diagnosis of renal cell carcinoma, admitted to the hospital with symptoms of acute pancreatitis at the 8th year of pazopanib treatment.
The patient diagnosed with renal cell carcinoma was admitted to the hospital with the complaint of abdominal pain, nausea, and vomiting in the 8th year of Pazopanib treatment. It was noticed from the patient's history that he had received Bitter Melon extract for 4 days prior to the beginning of his complaints (100-150 ml/day). Levels of serum amylase and lipase were measured as 9163 U/L and 14,206 U/L, respectively.
MANAGEMENT & OUTCOME: Pazopanib drug was held. The patient was treated for acute pancreatitis. Pazopanib treatment was started again after the clinical condition of the patient had improved and levels of serum amylase and lipase had returned to normal levels. Levels of serum amylase and lipase did not increase again after re-administration of pazopanib treatment.
It is thought that Bitter Melon extract and pazopanib interaction might have led to acute pancreatitis. To the best of our knowledge, this case is the first to highlight the interaction of Bitter Melon extract with pazopanib. The Drug Interaction Probability Scale indicates that there is a probable association between bitter melon and acute pancreatitis.
文献中报道了与帕唑帕尼相关的急性胰腺炎。苦瓜（Momordica charantia）在许多地区传统上被用作民间药物。在本报告中，我们描述了一位 65 岁的患者，该患者被诊断患有肾细胞癌，在接受帕唑帕尼治疗的第 8 年因急性胰腺炎住院。
该患者被诊断患有肾细胞癌，在接受帕唑帕尼治疗的第 8 年因腹痛、恶心和呕吐而住院。从患者的病史中注意到，在出现症状前 4 天他曾服用苦瓜提取物（100-150ml/天）。血清淀粉酶和脂肪酶的水平分别为 9163U/L 和 14206U/L。
暂停帕唑帕尼药物。对患者进行了急性胰腺炎治疗。在患者的临床状况改善且血清淀粉酶和脂肪酶水平恢复正常后，重新开始帕唑帕尼治疗。重新开始帕唑帕尼治疗后，血清淀粉酶和脂肪酶水平没有再次升高。
据认为，苦瓜提取物和帕唑帕尼的相互作用可能导致了急性胰腺炎。据我们所知，这是首例强调苦瓜提取物与帕唑帕尼相互作用的案例。药物相互作用概率量表表明，苦瓜与急性胰腺炎之间存在可能的关联。
