基于网络的简短教育干预对日本儿童接种人乳头瘤病毒疫苗意愿的影响：随机对照试验。
Effect of a Brief Web-Based Educational Intervention on Willingness to Consider Human Papillomavirus Vaccination for Children in Japan: Randomized Controlled Trial.
机构信息
Department of Obstetrics and Gynecology, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, United States.
出版信息
J Med Internet Res. 2021 Sep 27;23(9):e28355. doi: 10.2196/28355.
BACKGROUND
The human papillomavirus (HPV) vaccination rate in Japan has fallen to nearly zero since the suspension of governmental proactive recommendations in 2013, owing to the development of purported adverse events.
OBJECTIVE
This study aimed to evaluate the effects of a brief web-based educational intervention using the theory of behavioral insights on the willingness of adults to consider the HPV vaccine for their daughters and sons.
METHODS
We recruited 1660 participants aged 20 years or older in March 2018 via a webpage and provided them with a 10-item questionnaire related to the following aspects: awareness regarding HPV infection and vaccination, willingness for immunization, and actions for prevention. We randomly stratified participants based on sex and age with or without a brief educational intervention involving scientific information presented in an easy-to-read format.
RESULTS
Only 484 (29.2%) of the respondents were aware of the benefits of HPV vaccination. Although only 352 (21.2%) of the respondents displayed a willingness for immunization of their daughters, there were 40 (4.8%) more respondents in the intervention group with this willingness (adjusted odds ratio [aOR] 1.32, 95% CI 1.04-1.69). In a subanalysis, the willingness toward vaccination for daughters in men was significantly higher in the intervention group (aOR 1.46, 95% CI 1.05-2.02). However, such a difference was not observed among women (aOR 1.20, 95% CI 0.83-1.73).
CONCLUSIONS
This study suggests that a brief web-based educational intervention increases the willingness of adults to consider the HPV vaccine for their children, especially among men. Thus, providing adequate information to men may be a useful strategy to improve the currently low rates of HPV vaccination.
TRIAL REGISTRATION
UMIN Clinical Trials Registry UMIN000049745 (UMIN-CTR); https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000049745.
背景
自 2013 年日本政府停止积极推荐 HPV 疫苗接种以来，由于所谓的不良反应的出现，HPV 疫苗接种率几乎降至零。
目的
本研究旨在评估基于行为洞察理论的简短网络教育干预对成年人考虑为子女接种 HPV 疫苗意愿的影响。
方法
我们于 2018 年 3 月通过网页招募了 1660 名 20 岁及以上的参与者，并向他们提供了 10 项与以下方面相关的问卷：对 HPV 感染和疫苗接种的认识、接种意愿和预防措施。我们根据性别和年龄对参与者进行随机分层，分为接受或不接受包含以易于阅读格式呈现的科学信息的简短教育干预组。
结果
只有 484 名（29.2%）受访者了解 HPV 疫苗接种的益处。虽然只有 352 名（21.2%）受访者表示愿意为女儿接种疫苗，但干预组中表示有此意愿的人数增加了 40 人（调整后的优势比[aOR]1.32，95%置信区间[CI]1.04-1.69）。在亚分析中，干预组中男性对女儿接种疫苗的意愿明显更高（aOR 1.46，95% CI 1.05-2.02）。然而，女性中并未观察到这种差异（aOR 1.20，95% CI 0.83-1.73）。
结论
本研究表明，简短的网络教育干预可提高成年人考虑为子女接种 HPV 疫苗的意愿，尤其是男性。因此，向男性提供足够的信息可能是提高目前 HPV 疫苗接种率的有效策略。
试验注册
UMIN 临床研究注册 UMIN000049745（UMIN-CTR）；https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000049745。
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