Suzuki Yukio, Sukegawa Akiko, Nishikawa Aya, Kubota Kazumi, Motoki Yoko, Asai-Sato Mikiko, Ueda Yutaka, Sekine Masayuki, Enomoto Takayuki, Hirahara Fumiki, Yamanaka Takeharu, Miyagi Etsuko
Department of Obstetrics and Gynecology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Yokohama City University School of Medicine, Yokohama, Japan.
J Obstet Gynaecol Res. 2019 May;45(5):994-1005. doi: 10.1111/jog.13929. Epub 2019 Feb 5.
The human papillomavirus (HPV) vaccination rate in Japan fell to nearly 0% following widespread coverage of possible adverse events. Developing a next approach to promote the effective prevention of HPV-related diseases including cervical cancer (CC) in Japan requires comprehensive understanding of knowledge and attitudes regarding CC prevention, HPV infection and HPV vaccination among the population including laypersons and medical professions in Japan.
A questionnaire survey was administered in a wide variety of settings in Japan. The questionnaire contained items on knowledge about CC, HPV infection and HPV vaccination; awareness of the HPV vaccine's effectiveness and associated adverse events; and attitudes toward the HPV vaccination for their daughters and for men/boys.
Of 3033 targeted people, complete survey responses were received from 1182 men and 1602 women (total: 2784). The male laypersons' group had significantly lower knowledge than did the female laypersons' group (adjusted odds ratio, aOR = 3.86, P < 0.001). Compared with the male laypersons' group, the female laypersons' group tended to have less positive attitudes toward HPV vaccination for their daughters (aOR = 0.78, P = 0.006), but the female laypersons' group showed more positive attitudes toward vaccinating men/boys (aOR = 1.93, P < 0.001).
The survey results indicated that men in Japan generally lacked knowledge and awareness of HPV-related diseases and their prevention. However, women had more negative attitudes toward HPV vaccination for their daughters than did men. Increasing male involvement in HPV prevention and changing women's perceptions of the HPV vaccine are essential steps to increase the HPV vaccination rate.
在广泛报道了可能的不良事件后，日本的人乳头瘤病毒（HPV）疫苗接种率降至近0%。要制定下一个促进日本有效预防包括宫颈癌（CC）在内的HPV相关疾病的方法，需要全面了解日本普通民众和医疗行业人员对CC预防、HPV感染和HPV疫苗接种的知识和态度。
在日本的各种场所进行了问卷调查。问卷包含有关CC、HPV感染和HPV疫苗接种的知识项目；对HPV疫苗有效性和相关不良事件的认识；以及对其女儿和男性/男孩接种HPV疫苗的态度。
在3033名目标人群中，收到了1182名男性和1602名女性的完整调查回复（总计2784人）。男性普通人群组的知识水平明显低于女性普通人群组（调整后的优势比，aOR = 3.86，P < 0.001）。与男性普通人群组相比，女性普通人群组对其女儿接种HPV疫苗的态度往往不那么积极（aOR = 0.78，P = 0.006），但女性普通人群组对男性/男孩接种疫苗的态度更为积极（aOR = 1.93，P < 0.001）。
调查结果表明，日本男性普遍缺乏对HPV相关疾病及其预防的知识和认识。然而，女性对其女儿接种HPV疫苗的态度比男性更为消极。增加男性对HPV预防的参与度并改变女性对HPV疫苗的看法是提高HPV疫苗接种率的关键步骤。
