Department of Opthalmology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Clinical Neurophysioloy Unit, Faculty of Medicine, Cairo University, Cairo, Egypt.
Int J Neurosci. 2023 Jul;133(7):791-796. doi: 10.1080/00207454.2021.1984237. Epub 2021 Oct 6.
Hypertension is a major health problem in both developing and developed countries. Hypertension causes retinal structural and functional impairment within the ganglion cell layer. Pattern electroretinogram (PERG) offers an objective simple tool for assessment of retinal ganglion cell function. To assess retinal dysfunction in hypertensive patients with or without signs of retinopathy using PERG.
This is a case control study, including ninety-eight eyes. Twenty-eight eyes of healthy subjects served as a control group (group I) and seventy eyes of patients with systemic hypertension, who were further subdivided into group II including 39 eyes of hypertensive patients with normal fundus and group III including 31 eyes of patients with signs of hypertensive retinopathy. All subjects were subjected to ophthalmological examination and electrophysiological assessment using PERG.
PERG implicit times were significantly prolonged and amplitudes were significantly reduced in patients with established hypertensive retinopathy. PERG abnormalities were detected in 96.8% of hypertensive retinopathy patients and 79.5% of hypertensive patients with normal fundus.
PERG can objectively assess retinal dysfunction in hypertensive patients and may be considered a promising tool for early detection of hypertensive retinopathy.
高血压是发展中国家和发达国家的一个主要健康问题。高血压会导致节细胞层内的视网膜结构和功能损伤。图形视网膜电图（PERG）提供了一种评估视网膜节细胞功能的客观、简单的工具。本研究旨在使用 PERG 评估有或无视网膜病变迹象的高血压患者的视网膜功能障碍。
这是一项病例对照研究，共纳入 98 只眼。28 只眼的健康受试者作为对照组（I 组），70 只眼的系统性高血压患者分为 2 组，其中 39 只眼的高血压患者眼底正常（II 组），31 只眼的高血压患者有视网膜病变迹象（III 组）。所有受试者均接受眼科检查和 PERG 电生理评估。
已确诊的高血压性视网膜病变患者的 PERG 潜伏期显著延长，振幅显著降低。高血压性视网膜病变患者中 96.8%和眼底正常的高血压患者中 79.5%检测到 PERG 异常。
PERG 可客观评估高血压患者的视网膜功能障碍，可作为早期发现高血压性视网膜病变的有前途的工具。
