Reijonen Pauliina, Peltonen Reetta, Tervahartiala Taina, Sorsa Timo, Isoniemi Helena
Transplantation and Liver Surgery, Abdominal Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Oncology. 2021;99(12):766-779. doi: 10.1159/000518955. Epub 2021 Sep 27.
Matrix metalloproteinases (MMPs) have been extensively studied in several malignancies, and myeloperoxidase (MPO) is a promising new prognostic biomarker. We investigated the prognostic value of MMP-8, MMP-9, and MPO, as well as carcinoembryonic antigen (CEA), CA19-9, and C-reactive protein (CRP) in colorectal cancer with operable liver metastases.
This study included 419 patients who underwent liver resection for colorectal metastases at the Helsinki University Hospital between 2000 and 2013. Serum samples were drawn before and 3 months after liver resection. We evaluated associations of MMP-8, MMP-9, MPO, CRP, CEA, and CA19-9 concentrations to disease-free survival (DFS) and overall survival (OS) using the Cox proportional hazards model and Kaplan-Meier log-rank method.
In univariate Cox regression analyses, pre- and postoperatively high MMP-8 (HR 1.53, 95% CI: 1.07-2.19, p = 0.021 and HR 1.45, 95% CI: 1.01-2.09, p = 0.044, respectively) associated with worse 10-year OS. Postoperatively high MPO indicated better 5-year DFS (HR 0.70, 95% CI: 0.54-0.90, p = 0.007). Elevated pre- and postoperative CEA and CA19-9 as well as postoperative CRP indicated impaired survival.
Pre- and postoperatively high MMP-8 associates with worse 10-year OS, and postoperatively high MPO associates with better 5-year DFS. CEA, CA19-9, and CRP are also prognostic.
基质金属蛋白酶（MMPs）已在多种恶性肿瘤中得到广泛研究，髓过氧化物酶（MPO）是一种很有前景的新预后生物标志物。我们研究了MMP - 8、MMP - 9、MPO以及癌胚抗原（CEA）、CA19 - 9和C反应蛋白（CRP）在可手术切除肝转移的结直肠癌中的预后价值。
本研究纳入了2000年至2013年期间在赫尔辛基大学医院接受肝转移灶切除手术的419例患者。在肝切除术前及术后3个月采集血清样本。我们使用Cox比例风险模型和Kaplan - Meier对数秩检验方法评估MMP - 8、MMP - 9、MPO、CRP、CEA和CA19 - 9浓度与无病生存期（DFS）和总生存期（OS）之间的关联。
在单因素Cox回归分析中，术前和术后MMP - 8水平高与10年总生存期较差相关（HR分别为1.53，95%CI：1.07 - 2.19，p = 0.021和HR 1.45，95%CI：1.01 - 2.09，p = 0.044）。术后MPO水平高表明5年无病生存期较好（HR 0.70，95%CI：0.54 - 0.90，p = 0.007）。术前和术后CEA及CA19 - 9升高以及术后CRP升高均表明生存期受损。
术前和术后MMP - 8水平高与10年总生存期较差相关，术后MPO水平高与5年无病生存期较好相关。CEA、CA19 - 9和CRP也具有预后价值。
