Department of Biomedical Sciences, School of Medicine and the Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Department of Surgery, School of Medicine and the Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Cells. 2021 Aug 29;10(9):2238. doi: 10.3390/cells10092238.
Schlafens (SLFN) are a family of genes widely expressed in mammals, including humans and rodents. These intriguing proteins play different roles in regulating cell proliferation, cell differentiation, immune cell growth and maturation, and inhibiting viral replication. The emerging evidence is implicating Schlafens in cancer biology and chemosensitivity. Although Schlafens share common domains and a high degree of homology, different Schlafens act differently. In particular, they show specific and occasionally opposing effects in some cancer types. This review will briefly summarize the history, structure, and non-malignant biological functions of Schlafens. The roles of human and mouse Schlafens in different cancer types will then be outlined. Finally, we will discuss the implication of Schlafens in the anti-tumor effect of interferons and the use of Schlafens as predictors of chemosensitivity.
SLFNs 是一类广泛表达于哺乳动物中的基因家族，包括人类和啮齿类动物。这些引人入胜的蛋白质在调节细胞增殖、细胞分化、免疫细胞生长和成熟以及抑制病毒复制方面发挥着不同的作用。新出现的证据表明 SLFNs 与癌症生物学和化疗敏感性有关。尽管 SLFNs 具有共同的结构域和高度的同源性，但不同的 SLFNs 作用不同。特别是，它们在某些癌症类型中表现出特定的、偶尔是相反的作用。这篇综述将简要总结 SLFNs 的历史、结构和非恶性生物学功能。然后概述人类和小鼠 SLFNs 在不同癌症类型中的作用。最后，我们将讨论 SLFNs 在干扰素抗肿瘤作用中的意义以及将 SLFNs 用作化疗敏感性预测因子的可能性。
