Department of Microbiology and Immunology, Jeju National University College of Medicine, Jeju 63241, Korea.
Department of Biomedicine & Drug Development, Jeju National University, Jeju 63241, Korea.
Viruses. 2022 Feb 21;14(2):442. doi: 10.3390/v14020442.
The Schlafen gene family encodes for proteins involved in various biological tasks, including cell proliferation, differentiation, and T cell development. Schlafens were initially discovered in mice, and have been studied in the context of cancer biology, as well as their role in protecting cells during viral infection. This protein family provides antiviral barriers via direct and indirect effects on virus infection. Schlafens can inhibit the replication of viruses with both RNA and DNA genomes. In this review, we summarize the cellular functions and the emerging relationship between Schlafens and innate immunity. We also discuss the functions and distinctions of this emerging family of proteins as host restriction factors against viral infection. Further research into Schlafen protein function will provide insight into their mechanisms that contribute to intrinsic and innate host immunity.
Slfen 基因家族编码参与多种生物学任务的蛋白质，包括细胞增殖、分化和 T 细胞发育。Slfens 最初在小鼠中被发现，并在癌症生物学以及它们在病毒感染期间保护细胞的作用的背景下进行了研究。该蛋白质家族通过对病毒感染的直接和间接影响提供抗病毒屏障。Slfens 可以抑制具有 RNA 和 DNA 基因组的病毒的复制。在这篇综述中，我们总结了 Slfens 的细胞功能以及它们与先天免疫之间新出现的关系。我们还讨论了这个新兴的蛋白质家族作为抗病毒感染的宿主限制因子的功能和区别。进一步研究 Slfens 蛋白的功能将深入了解它们在固有和先天宿主免疫中发挥作用的机制。
