Chai Weiwen, Eaton Sarah, Rasmussen Heather E, Tao Meng-Hua
Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, 1700 N 35th Street, Lincoln, NE 68583, USA.
Department of Biostatistics and Epidemiology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, TX 76107, USA.
Biomedicines. 2021 Aug 26;9(9):1093. doi: 10.3390/biomedicines9091093.
Lipid-soluble micronutrients may be beneficial to non-alcoholic fatty liver disease due to their important roles in metabolism and maintaining tissue functions. Utilizing 2017-2018 National Health and Nutrition Examination Survey, this study examined the potential overall and race/ethnicity-specific (black, Hispanic and white) associations of dietary lipid-soluble micronutrients (-tocopherol, retinol, vitamin D, β-carotene and total carotenoids) with hepatic steatosis. The analysis included 4376 adults (1037 blacks, 981 Hispanics, 1549 whites) aged ≥20 years who completed the transient elastography examination with dietary data available. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using logistic regressions. The age-adjusted prevalence of steatosis was 20.9% for blacks, 34.0% for Hispanics and 28.7% for whites. Overall, dietary α-tocopherol was inversely associated with steatosis (highest vs. lowest quartile: OR = 0.51, 95%CI = 0.35-0.74, = 0.0003). The associations remained significant among blacks (highest vs. lowest tertile: OR = 0.45, 95%CI = 0.26-0.77, = 0.002) and whites (highest vs. lowest tertile: OR = 0.56, 95%CI = 0.33-0.94, = 0.02). Higher α-tocopherol intake was associated with lower odds of steatosis among all ( = 0.016) and black participants ( = 0.003) classified as never/rare/occasional alcohol drinkers. There was a trend suggesting higher β-carotene intake with lower odds of steatosis ( = 0.01). Our results suggest potential protective effects of dietary vitamin E as α-tocopherol on steatosis particularly among blacks.
脂溶性微量营养素因其在新陈代谢和维持组织功能方面的重要作用，可能对非酒精性脂肪性肝病有益。本研究利用2017 - 2018年美国国家健康和营养检查调查，考察了膳食脂溶性微量营养素（α-生育酚、视黄醇、维生素D、β-胡萝卜素和总类胡萝卜素）与肝脂肪变性之间潜在的总体关联以及种族/族裔特异性（黑人、西班牙裔和白人）关联。分析纳入了4376名年龄≥20岁的成年人（1037名黑人、981名西班牙裔、1549名白人），这些人完成了瞬时弹性成像检查且有可用的饮食数据。使用逻辑回归估计比值比（OR）和95%置信区间（95%CI）。黑人的脂肪变性年龄调整患病率为20.9%，西班牙裔为34.0%，白人为28.7%。总体而言，膳食α-生育酚与脂肪变性呈负相关（最高四分位数与最低四分位数相比：OR = 0.51，95%CI = 0.35 - 0.74，P = 0.0003）。在黑人（最高三分位数与最低三分位数相比：OR = 0.45，95%CI = 0.26 - 0.77，P = 0.002）和白人（最高三分位数与最低三分位数相比：OR = 0.56，95%CI = 0.33 - 0.94，P = 0.02）中，这种关联仍然显著。在所有被归类为从不/很少/偶尔饮酒者中（P = 0.016）以及黑人参与者中（P = 0.003），较高的α-生育酚摄入量与较低的脂肪变性几率相关。有一个趋势表明，较高的β-胡萝卜素摄入量与较低的脂肪变性几率相关（P = 0.01）。我们的结果表明，膳食维生素E作为α-生育酚对脂肪变性可能具有保护作用，尤其是在黑人中。
